AI Article Synopsis

  • The Comparative Mouse Genomics Centers Consortium (CMGCC) is part of the Environmental Genome Project, aimed at identifying human SNPs linked to disease risk.
  • The CMGCC develops genetic mouse models that mirror human gene variants involved in cell cycle control, DNA replication, and DNA repair related to various human health issues.
  • They provide informatics resources and have a dedicated Genotype Database to facilitate information sharing and support the development of these mouse models.

Article Abstract

The Comparative Mouse Genomics Centers Consortium (CMGCC) is a branch of the Environmental Genome Project sponsored by the National Institute of Environmental Health Sciences (NIEHS) focusing upon the identification of human single nucleotide polymorphisms (SNPs) that may confer disease susceptibility within the human population. The goal of the CMGCC (http://www.niehs.nih.gov/cmgcc/) is to make genetic mouse models for human SNPs within cell cycle control, DNA replication and DNA repair genes that may be associated with human pathologies. In order to facilitate information sharing and analysis within the consortium a set of informatics resources have been generated to support the mouse model development efforts. The primary entry point for information about the mouse models developed by the consortium is through the CMGCC Genotype Database (http://mrages.niehs.nih.gov/genotype/), which maintains both a consortium specific and public access display of the available and developing mouse models.

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Source
http://dx.doi.org/10.1016/j.mrfmmm.2005.11.010DOI Listing

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