Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase.

Bioorg Med Chem Lett

Department of Chemistry, Keimyung University, 1000 Sindang-Dong, Dalseo-Gu, Daegu 704-701, Republic of Korea.

Published: April 2006

1,3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps.

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http://dx.doi.org/10.1016/j.bmcl.2005.12.074DOI Listing

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