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A potential inflammatory biomarker for advanced endometrial cancer treated with lenvatinib plus pembrolizumab.
J Obstet Gynaecol Res
January 2025
Department of Obstetrics and Gynecology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Introduction: To identify prognostic biomarkers that could predict how well patients will respond to lenvatinib/pembrolizumab (LEN/PEM). The utility of certain inflammatory biomarkers in endometrial liquid-based cytology (LBC) or peripheral blood samples, such as neutrophil counts, lymphocyte counts, and neutrophil-to-lymphocyte ratio (NLR) were explored.
Methods: The study included 25 patients with advanced or recurrent endometrial cancer who had received LEN/PEM between August 2018 and March 2024.
Poor Performance of Applicator Tampon-Based Self-Collection for Liquid-Based Cytology Among Women Attending a Tertiary Hospital in South Africa.
Diagn Cytopathol
December 2024
Department of Virological Pathology, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Background: The South African Cervical Cancer Prevention and Control Policy was updated in June 2017, recommending liquid-based cytology (LBC) as the preferred screening method and the investigation of self-sampling for cervical cancer screening.
Aim: To compare the performance of the Self Collection Cervical Health Screening Kit [SelfCerv (applicator tampon)] to the Cervex-Brush Combi for cytology screening. The study further aimed to compare high-risk (hr-) human papillomavirus (HPV) and LBC test results from both methods.
Let it shine: Autofluorescence of Papanicolaou-stain improves AI-based cytological oral cancer detection.
Comput Biol Med
December 2024
Centre for Image Analysis, Department of Information Technology, Uppsala University, Uppsala, Sweden. Electronic address:
Background And Objectives: Oral cancer is a global health challenge. The disease can be successfully treated if detected early, but the survival rate drops significantly for late stage cases. There is a growing interest in a shift from the current standard of invasive and time-consuming tissue sampling and histological examination, towards non-invasive brush biopsies and cytological examination, facilitating continued risk group monitoring.
View Article and Find Full Text PDFEvaluation of the cervical liquid-based cytology sample as a microbiome resource for dual diagnosis.
PLoS One
December 2024
Department of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, Republic of Korea.
Cervical cancer, which is mainly caused by oncogenic human papillomavirus subtypes, remains a significant global health challenge. Recent studies have indicated a connection between cervical cancer and the uterine microbiome, underscoring its importance. This study explored the potential of liquid-based cytology (LBC) samples, which are typically used for cytological analysis, in investigating the cervical microbiome.
View Article and Find Full Text PDFHPV genotype-specific prevalence and infection risks: A 10-year population-based study from the United States.
J Natl Cancer Inst
December 2024
Wolfson Institute of Population Health, Queen, Mary University of London, London, UK.
Background: Various studies have reported on the impact of human papillomavirus (HPV) vaccines. Here we present the largest population-based investigation of genotype-specific distributions over the decade following implementation of the 4-valent HPV vaccine (HPV6/11/16/18) in the United States.
Methods: Liquid-based cervical cytology samples from individuals aged 15-30 years undergoing cervical screening throughout New Mexico were tested by broad-spectrum HPV genotyping.
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