A 34-year-old woman was admitted to the hospital because of swelling of her right knee, and the result of the laboratory tests indicated anemia and leukocytopenia. A bone marrow examination showed dissemination of small to medium-sized abnormal lymphocytes with abundant and pale blue cytoplasm and a circumferential "hairy" projection in the hypocellular bone marrow. These cells were positive for tartrate-resistant acid phosphatase (TRAP) and for CD 19, CD 20, CD 25, CD 103 and SmIg kappa. The patient was diagnosed as having hypoplastic hairy cell leukemia and received cladribine (2-CdA) for seven days via continuous intravenous injection. The minimum white blood cell count was 300/microl at seven days after starting the therapy (day 7) and the neutrophil count recovered to more than 1500/microl on day 118. The patient achieved complete remission on day 140 without any episodes of severe infection and has remained in complete remission for more than one year. The treatment of hypocellular HCL with 2-CdA might be useful.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Untangling the Strands of Hairy Cell Leukemia: The Clinicopathological Spectrum over Eleven Years at a Tertiary Care Center.
Discoveries (Craiova)
June 2023
Onco-Pathology Department, Gujarat Cancer & Research Institute, Ahmedabad, India.
Background: Hairy Cell Leukemia (HCL) is an uncommon, indolent lymphoproliferative disorder of mature B lymphoid cells, accounting for 2% of all lymphoid tumors. The present study evaluated the clinical-hematological profile of HCL patients diagnosed at a single tertiary care center over a 11-year period.
Methods: The retrospective observational study was done between October 2010 and September 2021.
Hairy Polyp of the Nasopharynx Associated With Hypoplastic Soft Palate, Low Eustachian Tube Orifice, and Tonsil.
Ear Nose Throat J
February 2022
Department of ENT, Christian Medical College, Vellore, Tamil Nadu, India.
Atypical presentation of hairy cell leukemia: Significance of CD200 on flow cytometry.
J Cancer Res Ther
October 2018
Department of Hematology, SGPGI, Lucknow, Uttar Pradesh, India.
Hairy cell leukemia (HCL) is a rare, low-grade mature B-cell neoplasm with a characteristic clinical, morphological, immunophenotypic, and more recently described molecular (BRAF p.V600E mutation) profile. It typically affects middle-aged to elderly male who present with pancytopenia and massive splenomegaly.
View Article and Find Full Text PDFAplastic anemia - bone marrow failure (AA) is defined as pancytopenia with hypocellular bone marrow without signs of marrow fibrosis or of presence of abnormal cells. Recent studies showed that most of AA cases might be mediated by immune mechanisms. Toxic agent leads to expression of neoantigens or cryptic antigens on the surface of pluripotent hematopoietic stem cells with subsequent activation of immune effector cells and induction of stem cell apoptosis.
View Article and Find Full Text PDFOverexpression of LINCR in the developing mouse lung epithelium inhibits distal differentiation and induces cystic changes.
Dev Dyn
July 2015
Neonatal Research Center, Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Background: Lung maturation can be disrupted through pro-inflammatory processes including intra-uterine amniotic infection, mechanical ventilation, or oxidative stress. Lincr, originally identified as a gene induced in the lung by lipopolysaccharide (LPS), is also expressed in the developing lung. The Lung-inducible Neuralized-related C3HC4 RING domain (LINCR) protein is structurally related to Drosophila Neuralized, a regulator of the developmentally important Notch signaling pathway.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!