The results of prospective study on combined agent Ginkor Fort are presented. The study included 60 patients with variceal disease and clinical picture of chronic venous insufficiency (CVI), II-IV CEAP class. Besides the registration of common and well known subjective signs (lower limb pain, heaviness and discomfort feelings, night palsies and paresthesia, edema), the main outcome measures included the results of digital photo-plethysmography (PPG). Initial assessment demonstrated the decrease of both venous return time (To) and muscular-venous pump capacity (Vo) with the increase of CEAP class; the trend of To appeared to be statistically significant (p=0.0318). The treatment resulted in the regression of main clinical complaints according to the 6-score analog scale. PPG showed the rise of to from 19.5+/-4.9 s to 20.5+/-3.7 s, though this trend was statistically insignificant (p>0.05). Vo elevated significantly from 3.69+/-2.4% to 4.04+/-2.3% (p<0.05), demonstrating the grown functional capacities of leg pump. PPG with To and Vo analysis can be used in combination with ultrasonic examination for the quantitative assessment of venous outflow disturbances and accordingly, of the CVI severity. This method can serve as an indicator of conservative treatment effectiveness. Combined agent Ginkor Fort is feasible for adjunctive therapy in complex treatment of patients with lower limb CVI symptoms.
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