AI Article Synopsis
- The study looked at the effects of angiotensin II on noradrenaline release and vascular contraction in mesenteric arteries and veins of hypertensive rats treated with DPSPX.
- Findings showed that, in hypertensive rats, angiotensin II enhanced noradrenaline release but weakened its contractile effects, especially in veins compared to arteries.
- The results suggest that angiotensin II may have distinct roles at different receptor sites, potentially contributing to the changes seen in blood pressure regulation in hypertensive conditions.
Article Abstract
Prejunctional facilitation of [3H]noradrenaline release induced by sympathetic nerve stimulation and postjunctional contractile effects of angiotensin II were studied in the mesenteric artery and vein of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX)-hypertensive rats. Male Wistar rats received infusions of saline or DPSPX (90 microg/kg/h) i.p.. Blood pressure was determined by tail-cuff. The prejunctional effect of angiotensin II was similar in artery and vein preparations of control rats and was increased in DPSPX-hypertensive rats. In contrast, the contractile effect of angiotensin II was much more pronounced in the mesenteric vein than in the mesenteric artery of control rats and was markedly reduced in DPSPX-hypertensive rats. We conclude that (1) the increased prejunctional effect of angiotensin II may contribute to, while (2) the decreased contractile effect of angiotensin II may attenuate DPSPX-induced hypertension. This study also supports the hypothesis that pre- and postjunctional angiotensin II receptors are different.
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| http://dx.doi.org/10.1016/j.ejphar.2005.12.009 | DOI Listing |
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