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Mechanistic Insights into Amorphous Solid Dispersions: Bridging Theory and Practice in Drug Delivery.
Pharm Res
January 2025
Solid State Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
Improving the bioavailability of poorly water-soluble drugs presents a significant challenge in pharmaceutical development. Amorphous solid dispersions (ASDs) have garnered substantial attention for their capability to augment the solubility and dissolution rate of poorly water-soluble drugs, thereby markedly enhancing their bioavailability. ASDs, characterized by a metastable equilibrium where the active pharmaceutical ingredient (API) is molecularly dispersed, offer enhanced absorption compared to crystalline forms.
View Article and Find Full Text PDFTOPSIS prefabricated building construction evaluation based on interval-valued Pythagorean fuzzy numbers based on prospect theory.
Sci Rep
January 2025
Institute of Architectural Engineering, Shanghai Zhongqiao Vocational and Technical University, Shanghai, 201514, China.
Prefabricated buildings have a series of advantages such as high efficiency, energy savings, and environmental protection, and are being strongly promoted by the Chinese government. However, due to the late start of prefabricated buildings in China, the installation process of prefabricated components is relatively complex, leading to difficulties in quality and safety control. A novel evaluation methodology integrating the technique for order preference by similarity to ideal solution (TOPSIS) with prospect theory and interval-valued Pythagorean fuzzy numbers (IVPFNs) is proposed.
View Article and Find Full Text PDFEvaluating challenges and policy innovations for renewable energy development in a circular economy: A path to environmental resilience in Saudi Arabia.
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Renewable Energy Lab, College of Engineering, Prince Sultan University, Riyadh, 11586, Saudi Arabia. Electronic address:
Saudi Arabia is one of the largest greenhouse gas (GHG) emitters due to its heavy reliance on fossil fuels, has begun taking proactive steps to address climate change under Vision 2030. The initiative aims to reduce the country's GHG emissions. As part of this effort, the government is transitioning to renewable energy (RE) to decrease its dependency on oil and support sustainable environmental development.
View Article and Find Full Text PDFTemporal metacognition: Direct readout or mental construct? The case of introspective reaction time.
J Exp Psychol Gen
January 2025
Centre de Recherche en Psychologie et Neurosciences, Centre National de la Recherche Scientifique, Aix-Marseille Universite.
Deciphering whether and which mental processes are accessible for metacognitive judgments is a key question to understand higher cognitive functions. Paralleling the crucial role of reaction times (RT) for unraveling the temporal sequence of mental processes, a comparable chronometric approach can be employed at the second-order level through introspective reaction times (iRT) measures. Although mean iRT correlate with mean RT, suggesting good metacognitive abilities, this would not necessarily imply a direct readout of the duration of the underlying processes as participants may instead rely on inferences based on other salient, nontemporal, cues.
View Article and Find Full Text PDFE-waste recycling in an optimized way for copper recovery by leaching and a case study on E-waste generation and management in Dhaka city.
Heliyon
January 2025
Department of Chemical Engineering, Bangladesh University of Engineering and Technology (BUET), Dhaka, 1000, Bangladesh.
The widespread adoption of electronic devices has enhanced living standards but has also led to a surge in electronic waste (e-waste), creating serious environmental and health challenges. Although various methods exist to recover valuable metals from e-waste, each has notable drawbacks. Among these, chemical leaching with aqua regia is widely used but is both highly corrosive and hazardous.
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