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Single-Molecule Identification and Quantification of Steviol Glycosides with a Deep Learning-Powered Nanopore Sensor.
ACS Nano
September 2024
State Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China.
Steviol glycosides (SGs) are a class of high-potency noncalorie natural sweeteners made up of a common diterpenoid core and varying glycans. Thus, the diversity of glycans in composition, linkage, and isomerism results in the tremendous structural complexity of the SG family, which poses challenges for the precise identification and leads to the fact that SGs are frequently used in mixtures and their variances in biological activity remain largely unexplored. Here we show that a wild-type aerolysin nanopore can detect and discriminate diverse SG species through the modulable electro-osmotic flow effect at varied applied voltages.
View Article and Find Full Text PDFPatient experiences of a 10-weeks weight-neutral treatment program for clinical binge eating disorder in a higher weight population.
J Eat Disord
December 2023
Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Background: Weight based stigma might drive the development of both higher weight and binge eating disorder (BED). To improve treatment and outcomes, a deeper understanding of how stigma and shame are correlated in clinical encounters is needed. The current study was designed to gain insight into how participating in a 10-weeks weight-neutral treatment program for patients with binge eating disorder and higher weight was experienced.
View Article and Find Full Text PDFUnlocking the Capacity of Bismuth Oxide by a Redox Mediator Strategy for High-Performance Aqueous Zn-Ion Batteries.
ACS Appl Mater Interfaces
October 2023
Yangtze Dleta Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou 313001, China.
Many cathode materials store zinc ions based on the intercalation reaction mechanism in neutral aqueous Zn-ion batteries, and the structural design of the cathodes has been stuck in the curing mode by extending the ion diffusion channel. Here, we first develop halide ions to unlock the electrochemical activity of conversion-type BiO in aqueous Zn-ion batteries. Notably, the iodide ion shows the best performance compatibility with the BiO cathode.
View Article and Find Full Text PDFSavor the flavor: A randomized double-blind study assessing taste-enhanced placebo analgesia in healthy volunteers.
Clin Transl Sci
November 2022
Department of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Essen, Germany.
Placebo effects substantially contribute to analgesic treatment outcomes and might be leveraged to enhance gold-standard treatments. The taste of oral medications has been proposed to boost placebo effects. Here, we aimed at estimating how far the taste of an oral medication enhances placebo analgesia.
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