Total synthesis of (+)-lasonolide A.

Org Lett

Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78 Sho-machi, Tokushima 770-8505, Japan.

Published: February 2006

[structure: see text]. An enantiocontrolled total synthesis of (+)-lasonolide A has been accomplished by using the sequential cross metathesis and macrolactonization for the key assembly of the 20-membered polyene macrolide core of the natural product.

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http://dx.doi.org/10.1021/ol0527678DOI Listing

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