AI Article Synopsis
- Two new defects in the pentose phosphate pathway have been found in patients with unusual polyol profiles and unexplained neurological symptoms.
- The neurotoxicity of polyols was tested using a 'neurochip' model, specifically examining the effects of D-arabitol and ribitol on rat cortical neurons.
- No immediate impact on neuronal activity was detected, suggesting that polyols may contribute to brain dysfunction primarily through indirect mechanisms.
Article Abstract
To date, two new defects in the pentose phosphate pathway have been identified in patients with abnormalities in their polyol profiles. Some of them presented with neurological symptoms of so far unknown aetiology. The pathophysiological role of polyols, e.g. in the brain, is relatively unknown. We tested the neurotoxicity of polyols using a 'neurochip' model. After exposure of cortical rat neurons to D-arabitol and ribitol in increasing concentrations up to 10 mmol/L, the electrophysiological activity was measured. No acute effect on the spontaneous network activity of cortical neurons was observed. We speculate that polyols have only secondary effects on brain dysfunction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10545-005-0073-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
H-driven xylitol production in Cupriavidus necator H16.
Microb Cell Fact
December 2024
VTT Technical Research Centre of Finland Ltd., Tekniikantie 21, 02150, Espoo, Finland.
Background: Biocatalysis offers a potentially greener alternative to chemical processes. For biocatalytic systems requiring cofactor recycling, hydrogen emerges as an attractive reducing agent. Hydrogen is attractive because all the electrons can be fully transferred to the product, and it can be efficiently produced from water using renewable electricity.
View Article and Find Full Text PDFMetabolomic profiles of infants classified as sudden infant death syndrome: a case-control analysis.
EBioMedicine
December 2024
Department of Public Health Sciences, University of Virginia, School of Medicine, Charlottesville, VA, USA; Department of Family Medicine, University of Virginia, School of Medicine, Charlottesville, VA, USA.
Background: Sudden Infant Death Syndrome (SIDS) is a leading cause of postneonatal mortality. The absence of specific biomarkers of SIDS diagnosis and risk leaves a significant gap in understanding SIDS pathophysiology. Metabolomics offers an avenue to better understand SIDS biology and identifying potential biomarkers.
View Article and Find Full Text PDFComparative Conformational Analysis of Acyclic Sugar Alcohols Ribitol, Xylitol and d-Arabitol by Solution NMR and Molecular Dynamics Simulations.
Molecules
February 2024
Division of Structural Biology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Miyagi, Japan.
Ribitol (CHO) is an acyclic sugar alcohol that was recently identified in -mannose glycan on mammalian α-dystroglycan. The conformation and dynamics of acyclic sugar alcohols such as ribitol are dependent on the stereochemistry of the hydroxyl groups; however, the dynamics are not fully understood. To gain insights into the conformation and dynamics of sugar alcohols, we carried out comparative analyses of ribitol, d-arabitol and xylitol by a crystal structure database search, solution NMR analysis and molecular dynamics (MD) simulations.
View Article and Find Full Text PDFEffect of Acute Melatonin Injection on Metabolomic and Testicular Artery Hemodynamic Changes and Circulating Hormones in Shiba Goats under Sub-Tropical Environmental Conditions.
Animals (Basel)
May 2023
Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
The beneficial effects of melatonin were investigated to mitigate various detrimental effects and toxicity on reproductive performance. The present study aimed, for the first time, to explore the effect of intravenous melatonin injection on testicular artery hemodynamics (TH) and metabolomic changes, reproductive hormones in heat-stressed bucks. Ten bucks were randomly split into two groups (five each): (1) the melatonin group, treated with a single intravenous dose of melatonin solution containing 10 mg melatonin each, and (2) the control group, which was treated with 10 mL of the vehicle without melatonin.
View Article and Find Full Text PDFUnexpected reactivity related to support effects during xylose hydrogenation over ruthenium catalysts.
RSC Adv
December 2021
Catalysis, Polymerisation, Processes, Materials (CP2M), UMR 5128 - CNRS, Université Claude-Bernard Lyon 1 CPE-Lyon Villeurbanne F-69616 France
Xylose is a major component of hemicelluloses. In this paper, its hydrogenation to xylitol in aqueous medium was investigated with two Ru/TiO catalysts prepared with two commercial TiO supports. A strong impact of the support on catalytic performance was evidenced.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!