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The Efficacy of Single-Application NPWTi-d for the Salvage of Infected Breast Prostheses: A Multi-Center Study.
Plast Reconstr Surg Glob Open
January 2025
From the Division of Plastic Surgery, UC San Diego Health, San Diego, CA.
Background: Breast prosthesis infections are challenging and traditionally managed with prosthesis removal and delayed reconstruction. Single-application negative pressure wound therapy with instillation and dwell (NPWTi-d) has shown promise for salvaging infected implants, though prior studies have been small and heterogeneous. This study analyzes outcomes and compares protocols from four institutions.
View Article and Find Full Text PDFManagement dilemma of a peri-prosthetic intracapsular neck of femur fracture in a young patient: Importance of biomechanical considerations when weighing up decision to mobilise, fix or replace.
BMJ Case Rep
December 2024
Trauma and Orthopaedics, Lewisham and Greenwich NHS Trust, London, UK.
The Investigation and Management of Peri-Prosthetic Joint Infection After Total Knee Arthroplasty: An Update Based on the Latest British Orthopaedic Association Standard and Speciality Standard Guidelines.
Cureus
November 2024
Trauma and Orthopaedics, Whittington Health NHS Trust, London, GBR.
Peri-prosthetic joint infection (PJI) is a significant complication following total knee arthroplasty (TKA). Early identification and management are essential to prevent severe morbidity and mortality in these patients. Long-term complications of PJI include the need for multiple operations, disability, joint stiffness, reduced range of motion, and increased mortality.
View Article and Find Full Text PDF[Minimizing risk: evaluation of the relationship between femoral stem loosening and the risk of presenting with peri-prosthetic hip fracture].
Acta Ortop Mex
November 2024
Servicio de Cirugía Ortopédica y Traumatología, Hospital General Universitario Gregorio Marañón. Madrid, España.
Introduction: evaluation of predictors of periprosthetic fracture in loosened femoral stems.
Material And Methods: retrospective case-control study comparing aseptic loosened stems in two groups: cases: patients who experienced periprosthetic femoral fracture before replacement could be performed (n = 9). Controls: experienced prosthetic replacement without fracture (n = 19).
Isolation and Antibiofilm Activity of Bacteriophages against from Patients with Periprosthetic Joint Infection.
Viruses
October 2024
AO Research Institute Davos, 7270 Davos, Switzerland.
Article Synopsis
- - The study investigates the effectiveness of bacteriophage therapy as a treatment option for periprosthetic joint infections (PJI) that often resist conventional antibiotics, especially since a specific bacteria accounts for a high percentage of these cases.
- - Researchers isolated nine different phages from human skin and tested their ability to combat biofilms formed by the PJI-causing bacteria on titanium discs, with some phages showing strong bacteria-fighting abilities and biofilm disruption.
- - Results indicate that phage therapy significantly reduces bacterial load and may serve as a promising alternative or supplement to traditional antibiotics in treating infections related to orthopedic devices.
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