The electrocardiogramme and methods of prolonged ECG recording are sufficient for diagnosing most cardiac arrhythmias. They also provide some prognostic information and allow evaluation and follow-up of treatment. However, in some situations, endocavitary electrophysiological investigations are required when the diagnosis is uncertain, that more prognostic information is required or interventional techniques (endocavitary ablation) are envisaged. The aim of this report is to summarise the value and limitations of programmed ventricular stimulation. Many of its indications have been abandoned in terms of rhythm stratification in the face of more robust parameters, in particular the left ventricular ejection fraction. However, it retains a potential utility in terms of prognosis in arrhythmogenic right ventricular dysplasia, the Brugada syndrome and operated Tetralogy of Fallot. In any event, it is important to remember that studies resulting in diagnostic or therapeutic recommendations were performed with strict protocols of stimulation in selected patients and that these recommendations can only be applied when the evaluation protocols are respected. The indications of programmed ventricular stimulation will increase in the therapeutic field with the development of new techniques of 3D mapping, new systems of catheter guiding which should extend the indications of endocavitary ablation.
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Curr Cardiol Rep
January 2025
Pediatric Advanced Heart Failure and Heart Transplant Program, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS, USA.
Purpose Of Review: Traditionally viewed as a passive player in circulation, the right ventricle (RV) has become a pivotal force in hemodynamics. RV failure (RVF) is a recognized complication of primary cardiac and pulmonary vascular disorders and is associated with a poor prognosis. Unlike treatments for left ventricular failure (LVF), strategies such as adrenoceptor signaling inhibition and renin-angiotensin system modulation have shown limited success in RVF.
View Article and Find Full Text PDFJ Biophotonics
January 2025
Department of Electrical Engineering, Columbia University, New York, New York, USA.
Epicardial catheter ablation is necessary to address ventricular tachycardia targets located far from the endocardium, but epicardial adipose tissue and coronary blood vessels can complicate ablation. We demonstrate that catheter-based near-infrared spectroscopy (NIRS) can identify these obstacles to guide ablation. Eighteen human ventricles were mapped ex vivo using NIRS catheters with optical source-detector separations (SDSs) of 0.
View Article and Find Full Text PDFFASEB J
January 2025
National Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Microgravity-induced cardiac remodeling and dysfunction present significant challenges to long-term spaceflight, highlighting the urgent need to elucidate the underlying molecular mechanisms and develop precise countermeasures. Previous studies have outlined the important role of miRNAs in cardiovascular disease progression, with miR-199a-3p playing a crucial role in myocardial injury repair and the maintenance of cardiac function. However, the specific role and expression pattern of miR-199a-3p in microgravity-induced cardiac remodeling remain unclear.
View Article and Find Full Text PDFPLoS Genet
January 2025
Department of Molecular Biosciences, Program in Molecular, Cellular, and Developmental Biology, KU Center for Genomics, University of Kansas, Lawrence, Kansas, United States of America.
Recent studies in vertebrates and Caenorhabditis elegans have reshaped models of how the axon guidance cue UNC-6/Netrin functions in dorsal-ventral axon guidance, which was traditionally thought to form a ventral-to-dorsal concentration gradient that was actively sensed by growing axons. In the vertebrate spinal cord, floorplate Netrin1 was shown to be largely dispensable for ventral commissural growth. Rather, short range interactions with Netrin1 on the ventricular zone radial glial stem cells was shown to guide ventral commissural axon growth.
View Article and Find Full Text PDFPLoS One
January 2025
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Introduction: Haemodynamic atrioventricular delay (AVD) optimisation has primarily focussed on signals that are not easy to acquire from a pacing system itself, such as invasive left ventricular catheterisation or arterial blood pressure (ABP). In this study, standard clinical central venous pressure (CVP) signals are tested as a potential alternative.
Methods: Sixteen patients with a temporary pacemaker after cardiac surgery were studied.
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