AI Article Synopsis
- The endoplasmic reticulum chaperone BiP has important roles both inside and outside of cells, showing anti-inflammatory and immunomodulatory effects when outside.
- BiP activates anti-inflammatory gene expression in human monocytes and promotes the development of T-cells that release beneficial cytokines like interleukin-10 and interleukin-4.
- Due to its ability to prevent and treat collagen-induced arthritis, BiP is being considered as a potential new treatment for rheumatoid arthritis.
Article Abstract
The endoplasmic reticulum chaperone BiP, in addition to its many important intracellular functions, has anti-inflammatory and immunomodulatory properties when present in the extracellular environment by the stimulation of an anti-inflammatory gene programme from human monocytes and by the development of T-cells that secrete regulatory cytokines such as interleukin-10 and interleukin-4. It can both prevent as well as treat ongoing collagen-induced arthritis. It is, therefore, a potential new biologic therapy for rheumatoid arthritis.
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| http://dx.doi.org/10.1016/j.autrev.2005.08.006 | DOI Listing |
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