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The morphological spectrum of cheilitis.
J Am Acad Dermatol
January 2025
Department of Dermatology and Venereology, AIIMS, Bhubaneswar, India. Pin-751019.
Identification of Associations with Dermatologic Diseases through a Focused GWAS of the UK Biobank.
JID Innov
January 2025
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Article Synopsis
- The UK Biobank contains genotype data for around 500,000 individuals and over 7,000 traits, but many significant relationships are overlooked due to the vast number of tests conducted.
- This study focuses on 13 skin-related conditions and identifies 447 important genetic variants that are more likely to affect protein functions, along with a higher CADD score, indicating their potential impact.
- Through further analysis, the researchers not only confirmed existing pathways related to skin cancers but also discovered five new protein-coding variants linked to conditions like lipomas and systemic lupus erythematosus.
CHILDHOOD LICHEN PLANUS: A STUDY OF 54 CASES FROM PAKISTAN.
J Ayub Med Coll Abbottabad
November 2024
Combined Military Hospital, Bahawalpur-Pakistan.
Article Synopsis
- A cross-sectional study was conducted in Pakistan to analyze the clinical characteristics of Childhood Lichen Planus (LP) in patients under 15 years of age at a Tertiary Care Hospital from December 2021 to December 2023.
- The study found that the average age of onset was approximately 9.8 years, with 94.4% of patients experiencing pruritus; classic LP was the most common type identified.
- The research concluded that childhood LP is rare, closely resembles adult LP, and shows no significant gender preference, with instances of nail and mucosal involvement being particularly uncommon.
Dermoscopy Training Course Improves Ophthalmologists' Accuracy in Diagnosing Atypical Pigmented Periorbital Skin Lesions.
Diagnostics (Basel)
November 2024
Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy.
Article Synopsis
- Facial pigmented skin lesions are common, especially in South-European countries, and can be either malignant or benign; diagnosing them can be challenging, even for specialists like dermatologists.* -
- A study was conducted to assess the impact of a one-day dermoscopy training course on ophthalmologists, focusing on their ability to evaluate periorbital pigmented lesions through clinical and dermoscopic analysis.* -
- Results showed that before the training, ophthalmologists had an accuracy of 63.7%, but after the course, their sensitivity improved, indicating a positive effect of the training on their diagnostic skills.*
Photodynamic therapy in dermatology: established and new indications.
J Dtsch Dermatol Ges
December 2024
Center for Dermatology, Allergology and Dermatosurgery, Helios University Hospital Wuppertal, University of Witten/Herdecke, Wuppertal, Germany.
Photodynamic therapy (PDT) is internationally established as an approved treatment option for in situ forms of keratinocytic skin cancer (actinic keratoses, Bowen's disease, basal cell carcinoma). For these indications, there are standardized treatment protocols using narrow-spectrum light sources or (artificial) daylight, the use of which is associated with successful healing, a low rate of lesion recurrence, and a very good cosmetic result. Daylight PDT is superior to conventional PDT in terms of significantly less pain and associated higher patient acceptance.
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