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Global regional and national burden of intracerebral hemorrhage between 1990 and 2021.
Sci Rep
January 2025
Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Intracerebral hemorrhage (ICH) represents one of the most devastating forms of stroke, characterized by spontaneous bleeding into the brain parenchyma. This neurological emergency carries a substantial burden of mortality and long-term disability worldwide. A comprehensive understanding of ICH's evolving global impact from 1990 to 2021 remains essential for healthcare planning and resource allocation.
View Article and Find Full Text PDFPredicting functional outcomes of patients with spontaneous intracerebral hemorrhage based on explainable machine learning models: a multicenter retrospective study.
Front Neurol
January 2025
Department of Neurosurgery, Changshu Hospital Affiliated to Soochow University, Changshu, China.
Background: Spontaneous intracerebral hemorrhage (SICH) is the second most common cause of cerebrovascular disease after ischemic stroke, with high mortality and disability rates, imposing a significant economic burden on families and society. This retrospective study aimed to develop and evaluate an interpretable machine learning model to predict functional outcomes 3 months after SICH.
Methods: A retrospective analysis was conducted on clinical data from 380 patients with SICH who were hospitalized at three different centers between June 2020 and June 2023.
Catechin-Based Polyphenol Nanoparticles Ameliorated Ferroptosis to Alleviate Brain Injury after Intracerebral Hemorrhage.
ACS Appl Mater Interfaces
January 2025
Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang 550000, China.
Spontaneous intracerebral hemorrhagic stroke (ICH) is a highly aggressive disease, with a high incidence and mortality rate. Iron deposition following ICH leads to oxidative damage and motor dysfunction, significantly impacting the overall quality of life for those affected. Here, a polyphenolic nanomedicine, catechin-based polyphenol nanoparticles surface-modified by thiol-terminated poly(ethylene glycol) (CNPs@PEG), was developed through the oxidative polymerization and self-assembly of catechin, a natural compound in tea.
View Article and Find Full Text PDFDoes Celecoxib Actually Reduce Mortality in Patients with Spontaneous Intracerebral Hemorrhage?
Neurocrit Care
January 2025
Division of Neurocritical Care, Department of Neurology, Loyola University Stritch School of Medicine, Maywood, IL, USA.
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