Case Description: A 4-month-old Missouri Fox Trotter colt was examined for a 5-week history of head tilt after treatment for suspected pulmonary Rhodococcus equi infection.
Clinical Findings: Computed tomography revealed osteolysis of the occipital, temporal, and caudal portion of the parietal bones of the left side of the cranium. A soft tissue mass compressing the occipital region of the cerebral cortex and cerebellum was associated with the osteolytic bone.
Treatment And Outcome: A rostrotentorial-suboccipital craniectomy approach was performed to remove fragmented occipital bone, debulk the intracranial mass, and obtain tissue samples for histologic examination and bacterial culture. All neurologic deficits improved substantially within 3 days after surgery. Bacterial culture of the resected soft tissue and bone fragments yielded R equi.
Clinical Relevance: Intracranial surgery in veterinary medicine has been limited to dogs and cats; however, in select cases, extrapolation of surgical techniques used in humans and small animals can assist with intracranial procedures in horses.
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http://dx.doi.org/10.2460/javma.228.2.251 | DOI Listing |
PLoS One
January 2025
UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, Dublin, Ireland.
The multi-host pathogen Rhodococcus equi is a parasite of macrophages preventing maturation of the phagolysosome, thus creating a hospitable environment supporting intracellular growth. Virulent R. equi isolated from foals, pigs and cattle harbor a host-specific virulence plasmid, pVAPA, pVAPB and pVAPN respectively, which encode a family of 17 Vap proteins belonging to seven monophyletic clades.
View Article and Find Full Text PDFPol J Vet Sci
September 2024
Department of Companion Animals and Horses, University Equine Hospital, Vetmeduni Vienna, Vienna, Austria.
Rhodococcus equi (R. equi) is a primary cause of pyogranulomatous pneumonia of foals between three weeks and five months of age. Early diagnosis of rhodococcal pneumonia has always been considered a preferable approach as it can lead to more successful treatment and better outcomes.
View Article and Find Full Text PDFFront Vet Sci
December 2024
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.
Introduction: Platelet lysate (PL) demonstrates antimicrobial and anti-inflammatory properties offering potential for treatment of bacterial pneumonia in horses. It remains unknown whether nebulization is suitable for PL administration in horses. This pilot study characterized particle size and flow rate of pooled equine PL (single preparation) nebulized using an equine-specific nebulizer (Flexivent).
View Article and Find Full Text PDFTierarztl Prax Ausg G Grosstiere Nutztiere
December 2024
Laboklin GmbH & Co. KG, Bad Kissingen, Germany.
Front Pharmacol
November 2024
INTHERES, INRAE, ENVT, University of Toulouse, Toulouse, France.
Introduction: causes life-threatening respiratory disease in foals. The standard treatment typically involves a combination of rifampicin and a macrolide antibiotic. Although previous studies have demonstrated the activity of these antibiotics against , the tested concentrations often do not reflect those achievable in foals.
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