Introduction: Even today, early recognition of sepsis remains a great problem, requiring the search for clinical symptoms and signs with predictive features.
Aim: to define the number of days of disease till hospitalization and value of some clinical signs in recognition and differentiation of patients with monomicrobial (M.A) gram positive and gram negative sepsis.
Patients And Methods: 200 patients with clear clinical and laboratory signs of sepsis, septic shock and monomicrobial aerobic bacterial isolate were included randomly. Patients are divided into two equal groups.
Results: patients with gram negative (m.a.) sepsis are hospitalized earlier relating to patients with gram positive sepsis (X2= 24,345; p< 0.001). Significance of differences in two basic groups of sepsis is the most evident for heart murmur (t=6,703; p<0,0001), shivers (t=3,313; p<0,001), afebrility (t=16,148; p<0,001), fatigue-exhaustion (t=4,472; p<0,001), pulmonary manifestations (t=3,497; p<0,001).
Conclusions: results of investigation show the recognition of clinical symptoms and signs of sepsis, which enables the differentiation between gram positive and gram negative. Initially, this provides clinicians with a greater therapeutic reliability.
Download full-text PDF |
Source |
---|
Probiotics Antimicrob Proteins
January 2025
Enzyme and Microbial Technology Research Center, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.
The emergence of multidrug-resistant pathogens presents a significant global health challenge, which is primarily fuelled by overuse and misuse of antibiotics. Bacteria-derived antimicrobial metabolites offer a promising alternative strategy for combating antimicrobial resistance issues. Bacillus velezensis PD9 (BvPD9), isolated from stingless bee propolis, has been reported to have antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA).
View Article and Find Full Text PDFSci Rep
January 2025
Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia.
Extracellular vesicles (EVs) are nanosized lipid bilayer particles released by various cellular organisms that carry an array of bioactive molecules. EVs have diagnostic potential, as they play a role in intercellular interspecies communication, and could be applied in drug delivery. In contrast to mammalian cell-derived EVs, the study of EVs from bacteria, particularly Gram-positive bacteria, received less research attention.
View Article and Find Full Text PDFSci Rep
January 2025
Laboratory of Extremophiles Biology, Department of Microbiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, Gdansk, 80-308, Poland.
In this study, we evaluated the combined effect between MLE-15, a modular lytic enzyme composed of four building blocks, and reline, a natural deep eutectic solvent. The bioinformatic analysis allowed us to determine the spatial architecture of MLE-15, whose components were bactericidal peptide cecropin A connected via a flexible linker to the cell wall binding domain (CBD) of mesophilic 201ϕ2 - 1 endolysin and catalytic domain (EAD) of highly thermostable Ph2119 endolysin. The modular enzyme showed high thermostability with the melting temperature of 93.
View Article and Find Full Text PDFFEMS Microbiol Lett
January 2025
Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8556, Japan.
Latilactobacillus curvatus, found in various fermented foods, is a promising probiotic with unique health benefits. Lipoteichoic acid (LTA) is a characteristic amphiphilic surface polymer of gram-positive bacteria and exhibits immunomodulatory activities. Despite the structural diversity of LTA among different bacterial species and strains, no information is available on the chemical structure of LTA in L.
View Article and Find Full Text PDFJ Biol Chem
January 2025
Department of Chemistry, University of California, Davis, California 95616, United States.
NysL, a cytochrome P450 monooxygenase from the Gram-positive bacterium Streptomyces noursei, catalyzes the C10 hydroxylation of 10-deoxynystain to nystatin A, a clinically important antifungal. In this study, we present the 2.0 Å resolution crystal structure of NysL bound to nystatin A.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!