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Concordance Between Asthma Symptom Reports and Objective Lung Function, and Associations With Sleep Outcomes in Urban Children.
Pediatr Pulmonol
January 2025
Department of Pediatrics, Hasbro Children's Hospital, Providence, Rhode Island, USA.
Objectives: To examine the extent to which asthma symptom concordance (ASC) or discordance (ASD) is associated with sleep outcomes in children with persistent asthma. Also, to investigate whether the association between ASC and sleep outcomes varies as a function of children's level of asthma control and severity.
Methods: A retrospective data analysis of Project NAPS (Nocturnal Asthma and Performance in School), an observational study which examined asthma and sleep outcomes in children with persistent asthma.
The effects of experimental sleep disruption on daytime performance among children with asthma living in urban environments.
Sleep Health
January 2025
Bradley-Hasbro Children's Research Center, Hasbro Children's Hospital, Providence, Rhode Island, USA; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA; Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Objectives: Children with asthma living in urban environments are at risk for disrupted sleep due to the presence of nocturnal asthma symptoms and urban stressors. Suboptimal sleep can affect children's daily functioning. The current study examined the effects of experimental sleep disruption on daytime performance in children with persistent asthma from urban backgrounds.
View Article and Find Full Text PDFThe relationship between the early life gastrointestinal microbiome and childhood nocturnal cough.
J Allergy Clin Immunol
January 2025
Department of Public Health Sciences, Henry Ford Health, Detroit, MI; Center for Bioinformatics, Henry Ford Health, Detroit, MI. Electronic address:
Background: Nocturnal cough affects approximately 1 in 3 children, can negatively impact child health, and is often attributable to asthma. The association of the gut microbiome with nocturnal cough has not been investigated.
Objective: To investigate the association between early-life gut microbiome composition and nocturnal cough overall and in the context of asthma.
[Characteristics of type 2 inflammation in nocturnal asthma and evaluation of the effectiveness of inhaled corticosteroids combination therapy].
Zhonghua Yi Xue Za Zhi
January 2025
Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou510515, China.
To investigate the characteristics of type 2 inflammation in patients with nocturnal asthma, and analyze the improvement of asthma symptoms after the use of inhaled corticosteroids (ICS) combined with different long-acting bronchodilators. Data of 231 asthma patients who first visited the Respiratory and Critical Care Medical Clinic of Nanfang Hospital of Southern Medical University from January 2020 to June 2023 and had positive bronchodilator tests (BDT), were retrospectively analyzed. These patients were divided into nocturnal asthma group and non-nocturnal asthma group based on the presence or absence of nocturnal symptoms.
View Article and Find Full Text PDFComputational Simulation Study-Based Formulation Development and Characterization of MethylprednisoloneLoaded Nanoparticles Containing Chitosan and Pectin to Treat Nocturnal Asthma.
Polymers (Basel)
December 2024
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Nocturnal asthma (NA) is a high-prevalence disease that causes severe respiratory issues, leading to death from early midnight to early morning. In this research, nanoparticulate drug delivery system of methylprednisolone (MP) was developed using chitosan (CH) and pectin (PEC). MP is a synthetic corticosteroid medication widely used for its potent anti-inflammatory activity.
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