Although gene therapy has huge potential for modern medicine, our enthusiasm for its powerful potential must not cloud our judgment about the dangers of using increasingly diverse, yet relatively untested, replicating viruses
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http://dx.doi.org/10.1136/bmj.332.7534.170 | DOI Listing |
Arch Dermatol Res
January 2025
Department of Dermatology and Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
JTO Clin Res Rep
January 2025
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Introduction: Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UTs) are a recently defined group of aggressive cancers in which the effectiveness of standard treatments for lung cancer is unknown.
Methods: We collected clinical, pathologic, and demographic variables from five institutions for patients whose tumors met criteria for SMARCA4-UTs (undifferentiated phenotype and loss of SMARCA4 (BRG1) by immunohistochemistry).
Results: We identified 92 patients with SMARCA4-UTs; 58 (63%) had stage IV disease at diagnosis and 16 (17%) developed recurrent or metastatic disease after initial diagnosis.
J Drug Deliv Sci Technol
February 2025
Department of Bioengineering, University of Louisville Speed School of Engineering, Louisville, KY, 40202.
Whether it be due to genetic variances, lack of patient adherence, or sub-optimal drug metabolism, the risk of antibiotic resistance from medications administered systemically continues to pose significant challenges to fighting infectious diseases. Ideally, infections would be treated locally for maximal efficacy while minimizing off-target effects. The electrospinning of biomaterials has recently facilitated the creation of electrospun nanofibers as an alternative delivery vehicle for local treatment.
View Article and Find Full Text PDFPalliat Support Care
January 2025
Division of Palliative Medicine, University of Kansas School of Medicine, Kansas City, KS, USA.
Objectives: Historically, patients with cancer were referred to palliative care near the end of life. In recent years, the increased integration of palliative care throughout the entire trajectory of illness has helped patients with cancer better manage their symptoms and improve QOL. However, it is unknown how patients think about the presence and role of earlier, integrated palliative care.
View Article and Find Full Text PDFFuture Oncol
January 2025
cKite, a Gilead Company, Santa Monica, CA, USA.
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