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Bioaccumulation of perfluorooctane sulfonic acid (PFOS) and oxidative stress in snapping turtles in New York, USA.
Environ Sci Pollut Res Int
January 2025
Department of Biology, Hamilton College, Clinton, NY, USA.
Perfluorooctane sulfonic acid (PFOS) is an anthropogenic chemical found in aqueous film-forming foams (AFFFs) and many consumer products. Despite its environmental ubiquity and persistence, little is known about the effects of PFOS on stress levels in wild animals. Here, we examined PFOS bioaccumulation and correlations between PFOS exposure and oxidative stress in snapping turtles (Chelydra serpentina) downstream of Griffiss Air Force Base in Rome, New York, a known source of AFFF contamination.
View Article and Find Full Text PDFThe interplay between retinoic acid binding proteins and retinoic acid degrading enzymes in modulating retinoic acid concentrations.
Curr Top Dev Biol
January 2025
Department of Pharmaceutics, School of Pharmacy, University of Washington.
The active metabolite of vitamin A, all-trans-retinoic acid (atRA), is critical for maintenance of many cellular processes. Although the enzymes that can synthesize and clear atRA in mammals have been identified, their tissue and cell-type specific roles are still not fully established. Based on the plasma protein binding, tissue distribution and lipophilicity of atRA, atRA partitions extensively to lipid membranes and other neutral lipids in cells.
View Article and Find Full Text PDFNeurofilament light chain - Can it be measured in urine?
Clin Chim Acta
January 2025
Department of Clinical Biochemistry, Aarhus University Hospital, Palle Juul Jensens Boulevard 99 8200 Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University 8000 Aarhus C, Denmark.
Objective: This exploratory study investigates if neurofilament light chain (NfL) is excreted in the urine and whether this depends on plasma NfL (pNfL) levels and kidney function in terms of eGFR and U-albumin-creatinine ratio (uACR).
Methods: Using a computer algorithm, we identified excess urine and plasma from routine testing of uACR and eGFR in patients 45-50 years old. Up to 17 paired urine-plasma samples in each of six categories of kidney function defined by uACR and eGFR were analysed for NfL, and the urinary NfL-creatinine ratio (uNCR) was calculated to correct for urine dilution.
Protein glycation compromises the bioavailability of milk protein-derived lysine in vivo in healthy adult males: a double-blind randomized cross-over trial.
Am J Clin Nutr
January 2025
Department of Human Biology, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, the Netherlands. Electronic address:
Background: Industrial processing and storage of milk products can strongly increase protein glycation level. Previously, we have reported that ingestion of highly glycated milk protein attenuates the post-prandial rise in plasma lysine concentrations when compared to the ingestion of an equivalent amount of milk protein with a low glycation level. Whether the attenuated increase in plasma lysine availability is attributed to compromised protein digestion and subsequent lysine absorption remains to be established.
View Article and Find Full Text PDFThe role of miRNAs in the associations between particulate matter and ischemic stroke: a nested case-control study.
Environ Pollut
January 2025
Department of Public Health, and Department of Endocrinology of the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, China. Electronic address:
Epidemiological studies have reported that atmospheric particulate matter (PM) contributes to ischemic stroke (IS). Biological studies also indicated that the pathway where PM induces IS involves several pathological processes. Moreover, exposure to PM can alter the expression of specific microRNAs (miRNAs) and ultimately accelerate the onset of IS by regulating related pathways.
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