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Thyroid function testing in pregnancy and thyroid disease: trimester-specific reference intervals. | LitMetric

Thyroid function testing in pregnancy and thyroid disease: trimester-specific reference intervals.

Ther Drug Monit

Department of Medicine, Division of Endocrinology and Metabolism, Lombardi Cancer Center, Washington, DC 20057-1465, USA.

Published: February 2006

During pregnancy the thyroid is hyperstimulated, resulting in changes in thyroid hormone concentrations. Accurate assessment of thyroid function during pregnancy is critical, for both the initiation of thyroid hormone therapy, and for the adjustment of thyroid hormone dose in those already receiving thyroid hormone. Trimester-specific intervals are especially important during pregnancy when thyroid insufficiency may be associated with adverse obstetric outcome and fetal neurodevelopmental deficits. Gestational age-specific reference intervals are now available for thyroid function tests. Knowing the expected normal changes in hormone concentrations throughout pregnancy allows individualized supplementation when necessary.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625634PMC
http://dx.doi.org/10.1097/01.ftd.0000194498.32398.7bDOI Listing

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