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| http://dx.doi.org/10.1186/bcr1373 | DOI Listing |
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Melanoma: Assessment and Management summary of 2022 update of the NICE guidelines.
Br J Dermatol
January 2025
Research fellow and General surgery trainee, Royal Marsden Hospital, London, UK.
Melanoma is the fifth most common skin cancer in the UK, accounting for 4% of all new cancer cases, with a predicted 7% increase in incidence between 2014-35. In parallel, since the initial publication of the Melanoma NICE Guidelines in 2015, there has been a paradigm shift in the management of the disease, with the introduction of effective systemic therapies. These innovations have reshaped the management of melanoma throughout the patient journey, and improved clinical outcomes.
View Article and Find Full Text PDFEvolving Strategies in the Management of Microsatellite Instability-High/Mismatch Repair Deficient Esophagogastric Adenocarcinoma.
Curr Oncol Rep
January 2025
Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Purpose Of Review: This review addresses the current treatment paradigm and new advancements in the management of microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) esophagogastric cancer (EGC).
Recent Findings: While chemotherapy and surgery remain the cornerstone of EGC treatment, MSI-H/dMMR tumors harbor high tumor mutational burden and represent a subset of patients who benefit from immune checkpoint inhibitors (ICI). ICI has been incorporated in the front line setting with and without chemotherapy for advanced disease.
Circadian Modulation of Behavioral Stress Responses in Zebrafish Is Age-Dependent.
J Exp Zool A Ecol Integr Physiol
January 2025
Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Emilia-Romagna, Italy.
In the wild, stressors occur with varying likelihood throughout the day, leading animals to evolve plastic stress responses that exhibit circadian rhythmicity. In mammals, studies have revealed that the circadian plasticity of stress response may differ with age. However, such developmental effects have been largely overlooked in other vertebrate groups.
View Article and Find Full Text PDFCurrent landscape of immunotherapy in esophageal cancer: a literature review.
J Thorac Dis
December 2024
Department of Surgery and Thoracic Surgery, Ascension Providence Hospital, Michigan State University College of Human Medicine, Southfield, MI, USA.
Background And Objective: Esophageal cancer has witnessed a significant shift in its epidemiology within the United States. Adenocarcinoma of the esophagus is now the fastest-growing solid malignancy, surpassing esophageal squamous cell carcinoma (ESCC) in frequency. There has been a concentrated effort to establish new therapies for dealing with this malignancy including immunotherapy in conjunction with surgery and radiotherapy.
View Article and Find Full Text PDFIris: A Next Generation Digital Pathology Rendering Engine.
J Pathol Inform
January 2025
University of Michigan Medical School, Department of Pathology, 2800 Plymouth Road, Ann Arbor, MI 48109-2800, USA.
Digital pathology is a tool of rapidly evolving importance within the discipline of pathology. Whole slide imaging promises numerous advantages; however, adoption is limited by challenges in ease of use and speed of high-quality image rendering relative to the simplicity and visual quality of glass slides. Herein, we introduce Iris, a new high-performance digital pathology rendering system.
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