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Oxytocin Receptors on Calvarial Periosteal Innervation: Therapeutic Target for Post-Traumatic Headache?
Pharmaceutics
June 2024
Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Objective: Following a mild traumatic brain injury (mTBI), the most prevalent and profoundly debilitating occurrence is the emergence of an acute and persistent post-traumatic headache (PTH), for which there are presently no approved treatments. A crucial gap in knowledge exists regarding the consequences of an mTBI, which could serve as a foundation for the development of therapeutic approaches. The activation of trigeminal sensory nerve terminals that innervate the calvarial periosteum (CP)-a densely innervated tissue layer covering the calvarial skull-has been implicated in both migraines and PTHs.
View Article and Find Full Text PDFBrain and the whole-body bone imaging appearances in Menkes disease: a case report and literature review.
BMC Pediatr
June 2024
Department of Radiology, West China Second University Hospital of Sichuan University, Chengdu, 610041, Sichuan Province, People's Republic of China.
Article Synopsis
- Menkes disease is a rare genetic disorder that affects copper metabolism, leading to various health issues, particularly in the nervous system and connective tissues.
- Diagnostic markers like serum copper and ceruloplasmin levels are unreliable, making imaging techniques crucial for identifying the disease.
- A case study of a 4-month-old boy highlighted significant neurological symptoms and imaging findings, confirming Menkes disease through genetic testing, but unfortunately, treatment did not improve his condition, resulting in his death three months later.
Can a single-needle periosteal acupuncture approach achieve more than a stellate ganglion block? Two case reports.
Acupunct Med
February 2024
Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Periosteal ganglion cyst of tibia: A rare case report.
Int J Surg Case Rep
July 2023
Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Pangeran Diponegoro Street number 71, Central Jakarta, Jakarta, Indonesia.
Article Synopsis
- Periosteal ganglion cysts are rare, affecting only 55 out of 100,000 people annually, and can cause damage to the bone surface.
- A 68-year-old male presented with a painless lump in his left leg, which was diagnosed as a periosteal ganglion cyst through MRI and confirmed by histopathology after excisional biopsy.
- The origin of these cysts is not well understood, but surgical treatment is necessary when symptoms persist, and complete removal is crucial to avoid recurrence, as evidenced by the patient's symptom-free status at six months post-surgery.
Metastatic Infiltration of Nervous Tissue and Periosteal Nerve Sprouting in Multiple Myeloma-Induced Bone Pain in Mice and Human.
J Neurosci
July 2023
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.
Multiple myeloma (MM) is a neoplasia of B plasma cells that often induces bone pain. However, the mechanisms underlying myeloma-induced bone pain (MIBP) are mostly unknown. Using a syngeneic MM mouse model, we show that periosteal nerve sprouting of calcitonin gene-related peptide (CGRP) and growth associated protein 43 (GAP43) fibers occurs concurrent to the onset of nociception and its blockade provides transient pain relief.
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