Objective: To intensively investigate sporadic CMT patients, we have analyzed the LMNA gene in this study in a series of 32 unrelated CMT patients.
Methods: Twelve exons of the LMNA gene were amplified from genetic DNA. PCR products of each exon were analyzed by single strand conformational polymorphism (SSCP).
Results: No abnormal SSCP pattern, suggesting no mutation in our CMT patients, was detected.
Conclusion: The CMT diseases resulted from the mutations of LMNA gene were rare.
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