Serum lipids and lipoproteins in patients with documented coronary artery disease.

Levels of various lipoprotein subclasses can provide useful information on coronary artery disease (CAD) risk status, even when traditional risk factors are known. Elevated serum level of lipids, lipoproteins and lipoprotein (a) have been identified as risk factor for atherosclerosis resulting in coronary artery disease, cerebrovascular disease, peripheral vascular disease and venous thromboembolism. The objective of this study is to evaluate the levels of serum lipids, lipoprotein and lipoprotein (a) in-patients suffering from documented coronary artery disease and normal healthy subjects. A case control study was conducted to evaluate the levels of lipid, lipoprotein and lipoprotein (a) in patients from our local population suffering from documented coronary artery disease. The present study was earned out in Dr. HMI Institute of Pharmacology & Herbal Sciences in collaboration with National Institute of Cardiovascular Diseases, Karachi from January 2001 to June 2001. One hundred and fifty persons were included in this case control study. Out of these one hundred were patients suffering from documented (coronary angiography done 4 month before the study) coronary artery disease (mean age 46.38 +/- 1.38, 18 females and 82 males). 50 normal healthy subjects (mean age, 44.86 +/- 1.15, 2 females and 48 males) had no history of IHD ever before. Their serum lipid, lipoprotein and lipoprotein (a) were estimated and compared.