AI Article Synopsis
- The study aimed to assess surgical outcomes and factors affecting prognosis in adults with intractable epilepsy due to focal cortical dysplasia (FCD).
- A retrospective analysis of 21 patients revealed that the majority, particularly those with shorter epilepsy duration, showed favorable seizure reduction post-surgery.
- Approximately 52% of patients became seizure-free, while others experienced significant decreases in seizure frequency, indicating that surgical intervention can be effective for select adults with FCD.
Article Abstract
Objectives: To determine the surgical outcome and prognostic factors in adult patients with intractable epilepsy and focal cortical dysplasia (FCD).
Materials And Methods: We retrospectively studied the operative outcome in 21 consecutive adult patients with FCD who underwent surgical treatment for intractable partial epilepsy.
Results: The mean age at surgery was 32.7 years (range, 18-58 years). The median post-operative follow-up was 2.5 years. The FCD was extratemporal in 11 patients, involved the temporal lobe in 10 patients, and was multilobar in eight patients. Eleven patients (52%) were rendered seizure-free, four patients (19%) had >95% reduction in seizures, and two patients (10%) had an 80-94% reduction in seizures. A seizure-free outcome was associated with shorter duration of epilepsy (P = 0.02).
Conclusion: Adult patients with FCD may be candidates for surgical treatment of intractable partial epilepsy. Most individuals have neocortical, extrahippocampal seizures and approximately 50% of patients are rendered seizure-free.
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| http://dx.doi.org/10.1111/j.1600-0404.2005.00548.x | DOI Listing |
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