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Enhanced Anticancer Efficiency of Curcumin Co-Loaded Lawsone Solid Lipid Nanoparticles Against MCF-7 Breast Cancer Cell Lines: Optimization by Statistical JMP Software-Based Experimental Approach.
Assay Drug Dev Technol
January 2025
Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education & Research - Autonomous, Anantapur, Andhra Pradesh, India.
Exploring Nile Red Staining as an Analytical Tool for Surface-Oxidized Microplastics.
Environ Res
January 2025
School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.; Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.; Institute for Open and Transdisciplinary Research Initiatives, Osaka University, 1-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Global Center for Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.. Electronic address:
Microplastics (MPs), defined as plastic particles smaller than 5 mm, have garnered considerable attention owing to their potential biological impact on human health. These particles exhibit a range of physicochemical properties, including size, shape, and surface oxidation. Nile Red is a prominent tool for detecting microplastics, enabling staining for dynamic analyses within biological systems.
View Article and Find Full Text PDFAntimicrobial Activity of UV-Activated and Cysteamine-Grafted Polymer Foils Against Bacteria and Algae.
Polymers (Basel)
January 2025
Centre for Nanomaterials and Biotechnology, Faculty of Science, University of Jan Evangelista Purkyně, Pasteurova 15, 400 96 Ústí nad Labem, Czech Republic.
Surface modification of various polymer foils was achieved by UV activation and chemical grafting with cysteamine to improve surface properties and antimicrobial efficacy. UVC activation at 254 nm led to changes in surface wettability and charge density, which allowed the introduction of amino and thiol functional groups by cysteamine grafting. X-ray photoelectron spectroscopy (XPS) confirmed increased nitrogen and sulfur content on the modified surfaces.
View Article and Find Full Text PDFSynergizing bioprinting and 3D cell culture to enhance tissue formation in printed synthetic constructs.
Biofabrication
January 2025
DWI-Leibniz-Institut für Interaktive Materialien, Forckenbeckstraße 50, Aachen, 52074, GERMANY.
Bioprinting is currently the most promising method to biofabricate complex tissues in vitro with the potential to transform the future of organ transplantation and drug discovery. Efforts to create such tissues are, however, almost exclusively based on animal-derived materials, like gelatin methacryloyl, which have demonstrated efficacy in bioprinting of complex tissues. While these materials are already used in clinical applications, uncertainty about their safety still remains due to their animal origin.
View Article and Find Full Text PDFAssessing the Efficacy of Pyrolysis-Gas Chromatography-Mass Spectrometry for Nanoplastic and Microplastic Analysis in Human Blood.
Environ Sci Technol
January 2025
Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia.
Humans are constantly exposed to micro- and nanosized plastics (MNPs); however, there is still limited understanding of their fate within the body, partially due to limitations with current analytical techniques. The current study assessed the appropriateness of pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) analysis for the quantification of a range of polymers in human blood. An extraction protocol that reduced matrix interferences (false positives) of polyethylene (PE) and polyvinyl chloride (PVC) was developed and validated.
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