In the first part of this study, we measured the alignment (relative to segmental landmarks) of the low F0 turning points between the accentual fall and the final boundary rise in short Dutch falling-rising questions of the form Do you live in [place name]? produced as read speech in a laboratory setting. We found that the alignment of these turning points is affected by the location of a postaccentual secondary stressed syllable if one is present. This is consistent with the findings and analyses of Grice, Ladd, & Arvaniti, 2000 (Phonology 17, 143-185), suggesting that the low turning points are the phonetic reflex of a "phrase accent." In the second part of this study, we measured the low turning points in falling-rising questions produced in a task-oriented dialog setting and found that their alignment is affected in the same way as in the read speech data. This suggests that read speech experiments are a valid means of investigating the phonetic details of intonation contours.
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http://dx.doi.org/10.1177/00238309050480020201 | DOI Listing |
Sci Rep
January 2025
College of Economics and Finance, Huaqiao University, Quanzhou, 362021, China.
High carbon sectors (agriculture, industry, construction, and transportation) contribute nearly 85% of carbon emissions, highlighting the urgent need for transitioning towards cleaner energy structures in these sectors. This study utilizes the undesirable SBM model to assess TFEE (total factor energy efficiency) across the total sector and high carbon sectors. It decomposes TFEE from an energy structural perspective into coal, oil, natural gas, and electric heat efficiencies.
View Article and Find Full Text PDFInt J Spine Surg
January 2025
Natural Resources Institute Finland, Natural Resources, Joensuu, Finland.
Background: The Oswestry Disability Index (ODI) is a well-validated and widely used patient-reported outcome instrument to evaluate lumbar spinal stenosis (LSS) patients' treatment outcomes. The objective of the present study was to determine long the average interval between 2 preoperative measurements can be before a clinically significant difference of 10 points or more might appear.
Methods: This was a retrospective observational study utilizing prospectively collected data from a single university hospital database, which was compatible with the national registry.
J Mol Diagn
February 2025
Daiichi Sankyo, Inc., Basking Ridge, New Jersey.
This study demonstrates the analytical and clinical validity of the approved (United States and Japan) plasma-based Guardant360 companion diagnostic (CDx) test for selecting patients with human epidermal growth factor receptor 2 (HER2 [ERBB2])-mutated (HER2m) non-small-cell lung cancer (NSCLC) for trastuzumab deruxtecan (T-DXd) treatment. Concordance between the Guardant360 CDx test and the plasma-based AVENIO ctDNA Expanded Kit Assay (AVENIO), as well as the tissue-based clinical trial assays (CTAs) was investigated. Clinical utility was assessed by comparing T-DXd clinical efficacy results of patients in DESTINY-Lung01/02 who tested positive for HER2 mutations using the Guardant360 CDx test to benchmark efficacy results from DESTINY-Lung01/02.
View Article and Find Full Text PDFACS Synth Biol
January 2025
Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany.
Cell-free synthetic biology incorporates purified components and/or crude cell extracts to carry out metabolic and genetic programs. While protein synthesis has historically been the primary focus, more metabolism researchers are now turning toward cell-free systems either to prototype pathways for cellular implementation or to design new-to-nature reaction networks that incorporate environmentally relevant substrates or new energy sources. The ability to design, build, and test enzyme combinations has accelerated efforts to understand metabolic bottlenecks and engineer high-yielding pathways.
View Article and Find Full Text PDFData Brief
February 2025
Economic and Social Research Institute, Dublin, Ireland.
This data article describes the operation of gas and oil fuelled residential heating systems in Ireland. Based on almost 10,000 homes, the data presents information on the operation of domestic heating systems (whether turned on/off by the user), and the firing of the boiler during 2-hour slots across a period of two years ending in September 2021 by geographical region. The electrification of heating is government policy, with the ambition that hundreds of thousands of homes will switch from oil and gas fuelled residential heating to heat pumps.
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