Enhanced funding of pharmacoepidemiology through patenting the disclosure of adverse event information.

Pharmacoepidemiol Drug Saf

Classen Immunotherapies, Inc., Montrose Avenue, Baltimore, MD 21212, USA.

Published: June 2006

Purpose: Known drug adverse events have been estimated to be between the 4th and 6th leading cause of death in the US (1). There are currently insufficient funds to perform the quantity and quality of studies necessary to ensure all drug adverse events are discovered in a timely fashion.

Methods/results: One approach to attract capital for pharmacoepidemiology studies is to patent the discoveries from the studies. Potential investors, whether executives of branded pharmaceutical companies or not, will consider funding pharmacoepidemiology studies if they can expect to receive competitive returns on their investments. Pharmacoepidemiolists who desire to patent their discoveries should seek novel drug-drug and drug-food interactions or negative interactions between drugs and certain phenotypes, genotypes or preexisting comorbidities.

Conclusion: These discoveries can lead to safer, and patentable, use of the drug by avoiding these interactions.

Download full-text PDF

Source
http://dx.doi.org/10.1002/pds.1206DOI Listing

Publication Analysis

Top Keywords

funding pharmacoepidemiology
8
drug adverse
8
adverse events
8
pharmacoepidemiology studies
8
patent discoveries
8
enhanced funding
4
pharmacoepidemiology patenting
4
patenting disclosure
4
disclosure adverse
4
adverse event
4

Similar Publications

Objective: To compare the effectiveness and safety of budesonide-glycopyrrolate-formoterol, a twice daily metered dose inhaler, and fluticasone-umeclidinium-vilanterol, a once daily dry powder inhaler, in patients with chronic obstructive pulmonary disease (COPD) treated in routine clinical practice.

Design: New user cohort study.

Setting: Longitudinal commercial US claims data.

View Article and Find Full Text PDF

Antipsychotic off-label use in the 21st century: An enduring public health concern.

Dialogues Clin Neurosci

December 2025

University Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, Bordeaux, France.

Soon after the introduction of second-generation antipsychotics, antipsychotic off-label use (OLU) progressively became a common prescribing practice. This evolving practice should be regularly monitored considering the growing number of persons exposed to the adverse effects of antipsychotics. The aim of the present review was to synthesise the literature published over the last 15 years on antipsychotic OLU for mental health symptoms.

View Article and Find Full Text PDF

Safety Assessment of Influenza Vaccination for Neurological Outcomes Among Older Adults in Japan: A Self-Controlled Case Series Study.

Pharmacoepidemiol Drug Saf

January 2025

Department of Clinical Epidemiology & Health Economics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Purpose: To assess adverse neurological risks following influenza vaccination in older adults.

Methods: Using a linked database of healthcare administrative claims data and vaccination records from an urban city in Japan (April 1, 2014, to March 31, 2020), we conducted an observational study utilizing a self-controlled case series design. We identified individuals aged ≥ 65 years who experienced adverse neurological outcomes, defined as hospitalizations related to epilepsy, paralysis, facial paralysis, neuralgia, neuritis, optic neuritis, migraine, extrapyramidal disorders, Guillain-Barre syndrome, or narcolepsy.

View Article and Find Full Text PDF

Purpose: Studies on antihypertensive treatment are important, as hypertension remains the major risk factor for cardiovascular morbidity and premature death. However, antihypertensive medicines are also used for other conditions, and the use of these medicines as a proxy for a diagnosis of hypertension might lead to misclassification in pharmacoepidemiological studies. This study aimed to investigate to what extent people dispensed antihypertensive medicines have been diagnosed with hypertension.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!