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A rare case of spinal myeloid sarcoma.
Surg Neurol Int
November 2024
Limburg Clinical Research Centre (LCRC), University of Hasselt, Hasselt, Belgium.
Background: Myeloid sarcoma (MS), a rare extramedullary tumor composed of myeloid blast cells, is classified by the World Health Organization as a subtype of acute myeloid leukemia (AML). Isolated, primary, or nonleukemic MS has an incidence of 2/1,000,000 adults and constitutes only 0.7% of all AML cases.
View Article and Find Full Text PDFEndocrine Perspective of Cutaneous Lichen Amyloidosis: -C634 Pathogenic Variant in Multiple Endocrine Neoplasia Type 2.
Clin Pract
October 2024
Department of Endocrinology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Background: Medullary thyroid carcinoma (MTC), the third most frequent histological type of thyroid malignancy, may be found isolated or as part of multiple endocrine neoplasia type 2 (MEN2). One particular subtype of this autosomal dominant-transmitted syndrome includes an association with cutaneous lichen amyloidosis, although, generally, a tide genotype-phenotype correlation is described in patients who carry proto-oncogene pathogenic variants.
Methods: Our objective was to provide an endocrine perspective of a case series diagnosed with -positive familial MTC associated with cutaneous primary lichen amyloidosis amid the confirmation of MEN2.
Thyroid Malignancy and Cutaneous Lichen Amyloidosis: Key Points Amid Pathogenic Variants in Medullary Thyroid Cancer/Multiple Endocrine Neoplasia Type 2 (MEN2).
Int J Mol Sci
September 2024
Department of Clinical Endocrinology V, C.I. Parhon National Institute of Endocrinology, 011863 Bucharest, Romania.
Article Synopsis
- This review focuses on the relationship between pathogenic variants related to medullary thyroid cancer (MTC) and multiple endocrine neoplasia type 2 (MEN2), especially considering their connection to cutaneous lichen amyloidosis (CLA).
- It highlights that most MEN2A patients with CLA have a specific pathogenic variant at codon 634, yet the connection between CLA and MTC remains poorly understood despite being recognized for over thirty years.
- The findings indicate that CLA usually appears early in life, often before MTC is diagnosed, and the relationship between mutations and CLA presentation can vary even within the same family.
Utilizing an ultrasound guided 5-in-1 trigger point and hydrodissection technique for interscapular mid-thoracic myofascial pain: A retrospective review.
Interv Pain Med
December 2023
Weill Cornell Medicine, Center for Comprehensive Spine Care, Department of Rehabilitation Medicine, New York, NY, USA.
Poor posture can lead to excessive strain of the neck and upper back musculature, leading to irritation of the dorsal scapular nerve (DSN) and spinal accessory nerve (SAN). A 5-in-1 trigger point technique has been described that specifically target trapezius, rhomboids, levator scapulae, SAN and DSN in a single percutaneous injection. We modified the technique to include hydrodissecting the DSN and SAN to provide further pain relief from possible nerve entrapments.
View Article and Find Full Text PDFAnatomical location, sex, and age modulate adipocyte progenitor populations in perivascular adipose tissues.
Front Physiol
July 2024
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, United States.
Perivascular adipose tissue (PVAT) regulates vascular function due to its capacity to synthesize vasoactive products and its mechanical properties. PVATs most abundant cells are adipocytes, and their populations are maintained by the maturation of adipocyte progenitor cells (APC), which may play a pivotal role in the pathogenesis of cardiovascular diseases. However, the distribution of APC within PVAT depots, their potential variation in spatial location, and the influence of sex and age on their abundance remain unknown.
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