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A Unique Case of a Massive Fungating Fibroadenoma of the Breast: Clinical and Pathological Insights.
Cureus
October 2024
General Surgery, Salmaniya Medical Complex, Manama, BHR.
Fibroadenoma is a type of benign tumor that occurs in breast tissues, commonly in younger age groups. However, the presentation of the patient described below shows how the disease presents in various manners. A 52-year-old woman presented to the outpatient clinic with a unilateral, giant, left-sided fungating breast mass who was later admitted under the General Surgical team, at Salmaniya Medical Complex (SMC) for further corresponding diagnostic workup.
View Article and Find Full Text PDFCentral nervous system manifestations of tuberous sclerosis complex: A single centre experience in Qatar.
Saudi Med J
November 2024
From the Department of Pediatrics (Aden, Fawzi), Division of Neurology; from the Department of Pathology (Prosser), Division of Pathology Genetics; from the Child and Adolescent Mental Health Services (Ather); from the Department of Anatomical imaging (Raja, Ederies), Division of Neuroradiology; from the Department of Surgery (Al-Kharazi), Division of Neurosurgery; and from the Department of Pediatrics (Maaz), Division of Hematology/Oncology, Sidra Medicine, Doha, Qatar.
Objectives: To review the clinical and radiological correlation of the central nervous system manifestations of tuberous sclerosis complex (TSC).
Methods: All patients under the age of 18 years with TSC seen at the Department of Pediatrics, Sidra Medicine, Doha, Qatar, between January 2003 and February 2021 were included in this retrospective study. Severity of epilepsy was determined using the early childhood epilepsy severity score (E-CHESS) tool.
Gene Expression Patterns in a Congenital Neurocristic Hamartoma With Multiple Proliferative Nodules.
J Cutan Pathol
February 2025
Department of Pathology, British Columbia Children's and Women's Hospitals, Vancouver, British Columbia, Canada.
Article Synopsis
- Cutaneous neurocristic hamartoma (CNH) is a rare skin lesion linked to unusual neural crest cell development, often mistaken for other conditions like giant congenital nevus.
- The study investigates gene expression differences between CNH and proliferative nodules (PNs) derived from it, comparing these with giant congenital nevus and malignant melanoma.
- Key findings indicate that lower levels of the tumor suppressor gene WIF1 in PNs might contribute to the growth of these nodules, while higher expression of IGF2 and H19 in CNH and PNs points to potential abnormal gene activity involved in CNH’s development.
Giant Complex Odontoma of the Posterior Mandible: A Case Report.
Cureus
September 2024
Department of Oral Pathology, Kothiwal Dental College and Research Centre, Moradabad, IND.
Complex odontoma is a benign odontogenic tumor composed of disorganized dental tissues, including enamel, dentin, cementum, and pulp. Unlike compound odontomas, which exhibit tooth-like structures, complex odontomas form a mass without anatomical organization. These tumors frequently present without symptoms and are typically identified inadvertently during standard dental imaging procedures.
View Article and Find Full Text PDFEverolimus on cystic kidney disease burden reduction in pediatric tuberous sclerosis complex patients: a case series.
BMC Nephrol
October 2024
Department of Pediatrics, Division of Nephrology, Saint Louis University, 1465 S Grand Blvd, St. Louis, MO, 62104, USA.
Background: Tuberous Sclerosis complex (TSC) is a multisystemic neurocutaneous genetic condition with high rates of morbidity and mortality from subependymal giant cell astrocytoma (SEGA), renal angiomyolipoma, and renal cyst complications. Everolimus is an inhibitor for mTORC1 and is currently used to treat TSC for its main role in rapidly reducing SEGA volume and seizure burden, although mainly studied in the adult population. It has also been shown to stabilize estimated glomerular filtration rate and reduce renal angiomyolipoma size in the adult population.
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