[reaction: see text] A highly stereoselective synthesis of l-2-deoxy-beta-ribo-hexopyranosyl nucleosides from 6-chloropurine and Boc-protected pyranone has been developed. Our approach relies on the iterative application of a palladium-catalyzed N-glycosylation, diastereoselective reduction, and reductive 1,3-transposition. This strategy is amenable to prepare various natural and unnatural hexopyranosyl nucleosides analogues.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546502 | PMC |
| http://dx.doi.org/10.1021/ol052664p | DOI Listing |
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