Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and a risk factor for cardiovascular disease. Although the relationship between aging and insulin resistance has been well shown, precise mechanism of age-related insulin resistance still remain unknown. Insulin action may deteriorate with age mediated through accumulation of abdominal fat rather than aging per se. Recently it has been reported that intramyocellular lipid content and hepatic lipid content which are related to insulin resistance are increased in elderly. Alternation of fat distribution by aging may be related to age-related insulin resistance.
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