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A new twist on superantigen-activated autoimmune disease.
J Clin Invest
January 2025
Division of Rheumatology, Center of Excellence for Intestinal and Immunology Research, University of Alberta, Edmonton, Alberta, Canada.
Superantigen-induced (Sag-induced) autoimmunity has been proposed as a mechanism for many human disorders, without a clear understanding of the potential triggers. In this issue of the JCI, McCarthy and colleagues used the SKG mouse model of rheumatoid arthritis to characterize the role of Sag activity in inflammatory arthritis by profiling arthritogenic naive CD4+ T cells. Within the diseased joints, they found a marked enrichment of T cell receptor-variable β (TCR-Vβ) subsets that were reactive to the endogenously encoded mouse mammary tumor virus (MMTV) Sag.
View Article and Find Full Text PDFEmerging strategies in outpatient endoscopy sedation management: Recent trends and developments.
World J Gastrointest Endosc
December 2024
Department of Gastroenterology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
In this article we comment on the article by Walayat . Outpatient endoscopy has become vital in modern healthcare, providing efficient diagnostic and therapeutic interventions with minimal patient disruption. This study highlighted the key developments in sedation management, focusing on risk stratification and procedural settings to enhance safety.
View Article and Find Full Text PDFComment on "Factors associated with leakage after reversal of protective stoma in patients with locally advanced rectal cancer following curative resection and anastomosis".
Eur J Surg Oncol
December 2024
Department of Anorectal Surgery, Ningbo No.2 Hospital, Ningbo, Zhejiang, China. Electronic address:
Reply to: Comment on Factors associated with leakage after reversal of protective stoma in patients with locally advanced rectal cancer following curative resection and anastomosis.
Eur J Surg Oncol
November 2024
Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
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