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Positive and negative ions of the amino acid histidine formed in low-energy electron collisions.
J Mass Spectrom
October 2019
Institut für Ionenphysik und Angewandte Physik and Center for Molecular Biosciences Innsbruck (CMBI), Universität Innsbruck, Technikerstraße 25, 6020, Innsbruck, Austria.
Histidine is an aromatic amino acid crucial for the biological functioning of proteins and enzymes. When biological matter is exposed to ionising radiation, highly energetic particles interact with the surrounding tissue which leads to efficient formation of low-energy electrons. In the present study, the interaction of low-energy electrons with gas-phase histidine is studied at a molecular level in order to extend the knowledge of electron-induced reactions with amino acids.
View Article and Find Full Text PDFAnalysis of Global and Site-Specific Radiation Damage in Cryo-EM.
Structure
May 2018
Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles CA 90095, USA; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA; Departments of Physiology and Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles CA 90095, USA. Electronic address:
Micro-crystal electron diffraction (MicroED) combines the efficiency of electron scattering with diffraction to allow structure determination from nano-sized crystalline samples in cryoelectron microscopy (cryo-EM). It has been used to solve structures of a diverse set of biomolecules and materials, in some cases to sub-atomic resolution. However, little is known about the damaging effects of the electron beam on samples during such measurements.
View Article and Find Full Text PDFInsights into Light-driven DNA Repair by Photolyases: Challenges and Opportunities for Electronic Structure Theory.
Photochem Photobiol
January 2017
Interdisciplinary Center for Scientific Computing, Ruprecht-Karls Heidelberg University, Heidelberg, Germany.
Ultraviolet radiation causes two of the most abundant mutagenic and cytotoxic DNA lesions: cyclobutane pyrimidine dimers and 6-4 photoproducts. (6-4) Photolyases are light-activated enzymes that selectively bind to DNA and trigger repair of mutagenic 6-4 photoproducts via photoinduced electron transfer from flavin adenine dinucleotide anion (FADH ) to the lesion triggering repair. This review provides an overview of the sequential steps of the repair process, that is light absorption and resonance energy transfer, photoinduced electron transfer and electron-induced splitting mechanisms, with an emphasis on the role of theory and computation.
View Article and Find Full Text PDFDirect-Write Fabrication of Cellulose Nano-Structures via Focused Electron Beam Induced Nanosynthesis.
Sci Rep
September 2016
Institute for Electron Microscopy and Nanoanalysis, Graz University of Technology, Steyrergasse 17, A-8010 Graz, Austria.
In many areas of science and technology, patterned films and surfaces play a key role in engineering and development of advanced materials. Here, we introduce a new generic technique for the fabrication of polysaccharide nano-structures via focused electron beam induced conversion (FEBIC). For the proof of principle, organosoluble trimethylsilyl-cellulose (TMSC) thin films have been deposited by spin coating on SiO2 / Si and exposed to a nano-sized electron beam.
View Article and Find Full Text PDFStructural characterization of actinomycin D using multiple ion isolation and electron induced dissociation.
J Am Soc Mass Spectrom
February 2014
Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
Non-ribosomal peptides are bio synthesized using a range of enzymes that allow much more structural variability compared with "normal" peptides. Deviations from the standard amino acid structures are common features of this diverse class of natural products, making sequencing a challenging process. FTICR mass spectrometry, specifically the complementary tandem mass spectrometry techniques collision activated dissociation (CAD) and electron induced dissociation (EID), have been used to reveal structural information on the non-ribosomal peptide actinomycin D.
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