Imidazo[1,2-a]pyrimidines are GABA(A) receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the alpha(3) subtype over the alpha(1) subtype. SAR studies to optimize this functional selectivity are described.
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| http://dx.doi.org/10.1016/j.bmcl.2005.11.112 | DOI Listing |
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