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Could Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?
Diagnostics (Basel)
November 2024
Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Background/objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies).
View Article and Find Full Text PDFGenomics and taxonomy of the glyphosate-degrading, copper-tolerant rhizospheric bacterium Achromobacter insolitus LCu2.
Antonie Van Leeuwenhoek
July 2024
Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), 13 Prospekt Entuziastov, Saratov, Russia, 410049.
Article Synopsis
- Achromobacter insolitus LCu2, isolated from alfalfa roots, can degrade 50% of glyphosate and tolerate high levels of copper and glyphosate-copper complexes.
- Inoculating alfalfa and potato plants with this strain enhanced their growth by 30-50% and reduced glyphosate toxicity compared to non-inoculated plants.
- The strain's genome indicates it has genes for promoting plant growth, degrading organophosphonates like glyphosate, and tolerating heavy metals, making it a promising candidate for improving crop yields and soil remediation.
Prediction of the Aggressive Clinical Course of Papillary Thyroid Carcinoma Based on Fine Needle Aspiration Biopsy Molecular Testing.
Int J Mol Sci
June 2024
Department of General and Pediatric Surgery, South Ural State Medical University, Chelyabinsk 454092, Russia.
Molecular genetic events are among the numerous factors affecting the clinical course of papillary thyroid carcinoma (PTC). Recent studies have demonstrated that aberrant expression of miRNA, as well as different thyroid-related genes, correlate with the aggressive clinical course of PTC and unfavorable treatment outcomes, which opens up new avenues for using them in the personalization of the treatment strategy for patients with PTC. In the present work, our goal was to assess the applicability of molecular markers in the preoperative diagnosis of aggressive variants of papillary thyroid cancer.
View Article and Find Full Text PDFModel of age-dependent dynamics and biokinetics of T-cells as natural biodosimeters.
Radiat Environ Biophys
August 2024
Mathematical Analysis Department, South Ural State University, Chelyabinsk, Russia.
Circulating T-lymphocytes are used as "natural biodosimeters" for estimating radiation doses, since the frequency of chromosomal aberrations induced in them is proportional to the accumulated dose. Moreover, stable chromosomal aberrations (translocations) are detected years and decades after exposure. Internal incorporation of radionuclides often leads to non-uniform exposure, which resulted in difficulties in the application of retrospective biodosimetry using T-lymphocytes.
View Article and Find Full Text PDFEvolution and genetic architecture of sex-limited polymorphism in cuckoos.
Sci Adv
April 2024
Division of Evolutionary Biology, LMU Munich, Planegg-Martinsried, Germany.
Article Synopsis
- Sex-limited polymorphism, which is the presence of different traits in males and females, has been observed in various species, including humans, but its genetic and evolutionary mechanisms are not fully understood.
- The common cuckoo is highlighted for its female-only color variation, where females can be either gray or rufous, influenced by negative frequency-dependent selection, which protects the rarer morph from male harassment and host species conflict.
- Research indicates that this color variation is genetically linked to a female-restricted genome and shares ancestry with a closely related species, the oriental cuckoo, demonstrating how sex-specific traits can arise and persist across different species.
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