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RBB1 negatively regulates rice disease resistance by modulating protein glycosylation.
J Integr Plant Biol
December 2024
Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, China.
Glycosylation, a prevalent post-translational modification in eukaryotic secreted and membrane-associated proteins, plays a pivotal role in diverse physiological and pathological processes. Although UDP-N-acetylglucosamine (UDP-GlcNAc) is essential for this modification, the specific glycosylation mechanisms during plant leaf senescence and defense responses remain poorly understood. In our research, we identified a novel rice mutant named rbb1 (resistance to blast and bacterial blight1), exhibiting broad-spectrum disease resistance.
View Article and Find Full Text PDFBeyond Lux: methods for species and photoreceptor-specific quantification of ambient light for mammals.
BMC Biol
November 2024
Centre for Biological Timing, Division of Neuroscience, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, M13 9PT, UK.
Article Synopsis
- Light plays a crucial role in regulating the physiology and behavior of mammals, and improper light exposure can lead to health issues due to disrupted circadian rhythms.
- The study introduces a new method for measuring light using a photoreceptor-specific (α-opic) approach that accounts for variations across different mammalian species and their unique photoreceptor types.
- Results show that α-opic measurements provide better predictions of physiological responses to light than the traditional lux measurements, potentially enhancing animal welfare, scientific research, agriculture, and energy efficiency.
Bioengineering breakthroughs: The impact of stem cell models on advanced therapy medicinal product development.
World J Stem Cells
October 2024
Laboratory of Extracellular Matrix Biology and Cellular Interaction, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508000, São Paulo, Brazil.
The burgeoning field of bioengineering has witnessed significant strides due to the advent of stem cell models, particularly in their application in advanced therapy medicinal products (ATMPs). In this review, we examine the multifaceted impact of these developments, emphasizing the potential of stem cell models to enhance the sophistication of ATMPs and to offer alternatives to animal testing. Stem cell-derived tissues are particularly promising because they can reshape the preclinical landscape by providing more physiologically relevant and ethically sound platforms for drug screening and disease modelling.
View Article and Find Full Text PDFNovel genomic and phenotypic traits of polyhydroxyalkanoate-producing bacterium ZZQ-149, the type strain of Halomonas qinghailakensis.
BMC Microbiol
September 2024
Institute of Plant Protection and Soil Science, Hubei Academy of Agricultural Sciences, Wuhan, 430064, China.
Background: Polyhydroxyalkanoates (PHAs) are optimal potential materials for industrial and medical uses, characterized by exceptional sustainability, biodegradability, and biocompatibility. These are primarily from various bacteria and archaea. Bacterial strains with effective PHA formation capabilities and minimal production cost form the foundation for PHA production.
View Article and Find Full Text PDFFunctional Effects of Probiotic Lactiplantibacillus plantarum in Alleviation Multidrug-Resistant Escherichia coli-Associated Colitis in BALB/c Mice Model.
Probiotics Antimicrob Proteins
September 2024
Lab of Bioresource, College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.
Multidrug-resistant Escherichia coli (MDR-E. coli) is a global health concern. Lactic acid bacteria (LAB) are important probiotics that have beneficial effects on health, and in recent years, their influences in preventing foodborne pathogens-induced colitis have attracted much attention.
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