The present paper presents the results of a study of hemodynamic features in 83 patients with intraocular tumors (74 uveal melanomas and 9 solitary choroidal hemangiomas), by applying high-frequency duplex scanning with color Doppler coding and Doppler spectral analysis of flows. The tumors in question are shown to differ in the qualitative and quantitative indicators of blood flow, which can be successfully used in the complex differential diagnosis and in the adjustment of management policy in the patients of this category.
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Mol Cancer Res
January 2025
Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon.
Dietary exposure to aflatoxin B1 (AFB1) is a risk factor for the development of hepatocellular carcinomas. Following metabolic activation, AFB1 reacts with guanines to form covalent DNA adducts, which induce high-frequency G > T transversions. The molecular signature associated with these mutational events aligns with the single-base substitution signature 24 (SBS24) in the Catalog of Somatic Mutations in Cancer database.
View Article and Find Full Text PDFCells
August 2024
Department of Pathology, Northwestern University, Chicago, IL 60611, USA.
Over 70% of leiomyoma (LM) harbor mutations, primarily in exon 2 at c.130-131 (GG). Myometrial cells are the cell origin of leiomyoma, but the MED12 mutation status in non-neoplastic myometrial cells is unknown.
View Article and Find Full Text PDFFront Med (Lausanne)
July 2024
Department of Clinical Physiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Objective: The objective of this study was 2-fold: first, to evaluate whether superb microvascular imaging (SMI) could be used to visualize neovascularization in temporal arteries, and, second, to evaluate the diagnostic performance of high frequency ultrasound with SMI using an extended protocol in patients with suspected giant cell arteritis (GCA).
Methods: This retrospective study comprised 120 patients consecutively examined with an extended CDU protocol (temporal, facial, axillary, subclavian, brachiocephalic, and carotid arteries) between 2020 and 2022. Of all patients, 107 had no previous GCA diagnosis and 13 had a previous GCA diagnosis.
Dokl Biochem Biophys
August 2024
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University of the Ministry of Health Care of the Russian Federation (Sechenov University), Moscow, Russia.
Unlabelled: The aim of the study was to evaluate the clinical manifestations and survival of patients with giant cell arteritis (GCA).
Materials And Methods: . A retrospective study included 166 patients with newly diagnosed GCA.
J Clin Med
June 2024
Division of Plastic and Reconstructive Surgery, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.
Ultrasound has revolutionized reconstructive microsurgery, offering real-time imaging and enhanced precision allowing for preoperative flap planning, recipient vessel identification and selection, postoperative flap monitoring, and lymphatic surgery. This narrative review of the literature provides an updated evidence-based overlook on the current applications and emerging frontiers of ultrasound in microsurgery, focusing on free tissue transfer and lymphatic surgery. Color duplex ultrasound (CDU) plays a pivotal role in preoperative flap planning and design, providing real-time imaging that enables detailed perforator mapping, perforator suitability assessment, blood flow velocity measurement, and, ultimately, flap design optimization.
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