The paper presents a work of art showing a presumably myasthenic patient painted more than 50 years before the disease was first described.
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http://dx.doi.org/10.1159/000090721 | DOI Listing |
J Clin Neurosci
April 2021
Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
In the early 20th century, a tumultuous era was yielding geopolitical and social change. Europe at large was undergoing redefinition of borders, political structures, and economies, while rebuilding societies after World War I. At the same time, neurosurgery was emerging as a new specialty, and women were allowed to study medicine for the first time in many European countries.
View Article and Find Full Text PDFNeurology
February 2021
From the Department of Ophthalmology and Visual Sciences, and the Center for History Of Medicine, Washington University School of Medicine, St. Louis, MO.
Henry R. Viets (1890-1969) was both a noted neurologist and medical historian. While at Harvard Medical School, from which he graduated in 1916, he attracted the attention of Harvey Cushing who directed Viets into these disciplines.
View Article and Find Full Text PDFNeuropharmacology
January 2021
University of Missouri, Columbia, 65212, MO, USA. Electronic address:
The beneficial effects of acetylcholinesterase inhibitors for the treatment of myasthenia gravis (MG) was a major discovery that came about through one young physician putting together a string of previous observations. To understand how this discovery came to light, we must first go back to earlier times when men hunted by bow-and-arrow to capture their prey. The substance used to poison the prey was eventually was identified as curare.
View Article and Find Full Text PDFJ R Coll Physicians Edinb
September 2019
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Mary Broadfoot Walker (1888-1974) was the first to demonstrate the 'Mary Walker effect' describing the weakness of other muscle groups following release of the arteriovenous occlusion of an unrelated exercising muscle group in patients with myasthenia gravis, which led to the search for a circulating causative agent for myasthenia gravis. She was the first to clearly demonstrate that strength temporarily improved in patients with myasthenia gravis with physostigmine or Prostigmin (neostigmine). This dramatic treatment response has been erroneously termed the 'Mary Walker effect'.
View Article and Find Full Text PDFZ Rheumatol
May 2016
Medizinhistorische Sammlung Gommern-Vogelsang, Archiv der Deutschen Gesellschaft für Rheumatologie, Am Kiefernhang 3, 39245, Gommern‑Vogelsang, Deutschland.
Dermatomyositis is a rare muscle disease that was first described by Ernst Leberecht Wagner and Heinrich Unverricht.After providing a survey on both scientists' life works, this contribution describes the most significant subsequent works on the diagnostics and classification of clinical symptoms and the progress of the disease that the author has been observing for more than three decades.Polymyositis/dermatomyositis (also known as Unverricht-Wagner or Wagner-Unverricht syndrome) was described in two publications by Ernst Leberecht Wagner in 1863 and 1887.
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