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Interleukin-3 Modulates Macrophage Phagocytic Activity and Promotes Spinal Cord Injury Repair.
CNS Neurosci Ther
December 2024
Department of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Effective clearance of lipid-rich debris by macrophages is critical for neural repair and regeneration after spinal cord injury (SCI). Interleukin-3 (IL-3) has been implicated in programming microglia to cluster and clear pathological aggregates in neurodegenerative disease. Yet, the influence of IL-3 on lipid debris clearance post-SCI is not well characterized.
View Article and Find Full Text PDFMitochondrial CLPB is a pro-survival factor at the onset of granulocytic differentiation of mouse myeloblastic cells.
Apoptosis
December 2024
Department of Biochemistry and Molecular Biophysics, Kansas State University, 141 Chalmers Hall, Manhattan, KS, 66506, USA.
Article Synopsis
- Loss-of-function mutations in the CLPB gene result in congenital neutropenia, impairing the differentiation of neutrophil precursor cells, though the underlying mechanism is unclear.
- In experiments using IL-3-dependent mouse myeloblastic 32Dcl3 cells, researchers found that CLPB knockout led to decreased mitochondrial membrane potential and increased HAX1 aggregates, but did not affect cell proliferation under IL-3.
- The increased apoptosis of CLPB-deficient cells after IL-3 withdrawal was linked to reactive oxygen species (ROS), with citrate supplementation showing potential to protect these cells by enhancing ROS detoxification through ATP-citrate lyase (ACLY) activity.
Effects of a single bout of exercise on human hemocytes and serum interleukin 3, erythropoietin, and soluble transferrin receptor in a hot and humid environment.
PeerJ
December 2024
College of Sports Science, Zhuhai College of Science and Technology, Zhuhai, Guangdong, China.
Article Synopsis
- The study examined how exercise at different intensities affects blood cell levels in hot and humid environments (HHEs) and its impact on physical and cognitive performance.* -
- Thirty-two participants were divided into groups based on exercise intensity (55%, 70%, and 85% of VOmax) and compared to a control group, all performed activities in HHE for 30 minutes.* -
- Results showed significant changes in various blood parameters due to exercise intensity, with notable effects on metrics like body mass, hemoglobin, and white blood cell count, particularly in low and moderate intensity groups.*
Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia.
Cancer Immunol Immunother
November 2024
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin, 300020, China.
Background: Immunotherapy, such as chimeric antigen receptor T (CAR-T) cells targeting CD33 or CD123, has been well developed over the past decade for the treatment of acute myeloid leukemia (AML). However, the inability to sustain tumor-free survival and the possibility of relapse due to antigen loss have raised concerns. A dual targeting of CD33 and CD123 is needed for better outcomes.
View Article and Find Full Text PDFCell Adhesion and Local Cytokine Control on Protein-Functionalized PNIPAM-co-AAc Hydrogel Microcarriers.
Small
November 2024
Chemical Process Engineering, RWTH Aachen University, Forckenbeckstr. 51, 52074, Aachen, Germany.
Achieving adequate cell densities remains a major challenge in establishing economic biotechnological and biomedical processes. A possible remedy is microcarrier-based cultivation in stirred-tank bioreactors (STBR), which offers a high surface-to-volume ratio, appropriate process control, and scalability. However, despite their potential, commercial microcarriers are currently limited to material systems featuring unnatural mechanical properties and low adaptability.
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