AI Article Synopsis
- The study aimed to analyze proton magnetic resonance spectroscopy (1H-ERM) data in Alzheimer's disease (AD) and Cognitive Impairment Not Dementia (CIND) in a community sample.
- Investigated subjects included 6 with AD, 7 with CIND, and 7 normal controls, focusing on brain metabolites like N-acetylaspartate (NAA), creatine (Cr), choline (Cho), and myo-inositol (mI) across different brain regions.
- The results showed that NAA levels were highest in controls, and specific metabolite patterns could correctly classify most subjects with AD versus controls and CIND versus controls, indicating the potential of spectroscopy for diagnosing cognitive impairment.
Article Abstract
Objective: To describe the proton magnetic resonance spectroscopy (1H-ERM) data in Alzheimer's disease (AD) and Cognitive Impairment Not Dementia (CIND) in a community sample.
Method: We investigated subjects with AD (n=6), CIND (n=7) and normal control (n=7). 1H-ERM was performed with single voxel (8 cm3) placed in temporal, parietal and occipital regions and studied metabolites were: N-acetylaspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mI).
Results: NAA concentration was higher in control subjects than AD and intermediated in CIND patients. Cho parietal plus occipital and Cr parietal plus Cho occipital classified correctly 92.3% of subjects Control vs AD. Temporal mI classified 78.6% of subjects between Control vs CIND.
Conclusion: Spectroscopy can be used in the diagnosis and follow-up of individuals with cognitive impairment; evaluation of community subjects may show different patterns of brain metabolites distribution.
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| http://dx.doi.org/10.1590/s0004-282x2005000600021 | DOI Listing |
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