Neurotropic viruses and cerebral palsy: population based case-control study.

BMJ

Department of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, 1st Floor Queen Victoria Building, 72 King William Road, Adelaide, SA 5006, Australia.

Published: January 2006

AI Article Synopsis

  • The study aimed to investigate the link between cerebral palsy and exposure to neurotropic viruses during the perinatal period.
  • The researchers conducted a case-control study involving 443 patients with cerebral palsy and 883 controls, testing for viral nucleic acids using newborn screening cards.
  • Findings revealed that a significant percentage of controls tested positive for viral nucleic acids, with herpes group B viruses increasing the risk of developing cerebral palsy, particularly in preterm infants.

Article Abstract

Objective: To investigate the association between cerebral palsy and direct evidence for perinatal exposure to neurotropic viruses.

Design: Population based case-control study.

Setting: Adelaide Women's and Children's Hospital Research Laboratory.

Participants And Main Outcome Measures: Newborn screening cards of 443 white case patients with cerebral palsy and 883 white controls were tested for viral nucleic acids from enteroviruses and herpes viruses by using polymerase chain reaction. Herpes group A viruses included herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus 8 (HHV-8), and herpes group B viruses included varicella zoster virus (VZV) and human herpes viruses 6 and 7 (HHV-6 and HHV-7).

Results: The prevalence of viral nucleic acids in the control population was high: 39.8% of controls tested positive, and the prevalence was highest in preterm babies. The detection of herpes group B viral nucleic acids increased the risk of developing cerebral palsy (odds ratio 1.68, 95% confidence interval 1.09 to 2.59).

Conclusions: Perinatal exposure to neurotropic viruses is associated with preterm delivery and cerebral palsy.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326927PMC
http://dx.doi.org/10.1136/bmj.38668.616806.3ADOI Listing

Publication Analysis

Top Keywords

cerebral palsy
20
viral nucleic
12
nucleic acids
12
herpes group
12
neurotropic viruses
8
population based
8
based case-control
8
perinatal exposure
8
exposure neurotropic
8
controls tested
8

Similar Publications

The purpose of this review was to examine the effects of hip muscle botulinum toxin injections for the treatment of hip instability reported in studies of children with cerebral palsy. Searches in PubMed, CINAHL, and Web of Science were performed using the term hips combined with botulinum toxin and its various abbreviations and brand names. Reference lists and citations of the reviewed studies were also searched.

View Article and Find Full Text PDF

Liposomes-Loaded miR-9-5p Alleviated Hypoxia-Ischemia-Induced Mitochondrial Oxidative Stress by Targeting ZBTB20 to Inhibiting Nrf2/Keap1 Interaction in Neonatal Mice.

Antioxid Redox Signal

January 2025

Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.

Hypoxia ischemia (HI) is a leading cause of cerebral palsy and long-term neurological sequelae in infants. Given that mitochondrial dysfunction in neurons contributes to HI brain damage, this study aimed to investigate the regulatory role of miR-9-5p in mitochondrial function following HI injury. Overexpression of miR-9-5p in HI mice or HO-exposed PC12 cells suppressed neuronal injury, associated with increased mitochondrial copy number, normalizing mitochondrial membrane potential, improved nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activation, and downregulation of Keap1.

View Article and Find Full Text PDF

According to the International League Against Epilepsy (ILAE) 2015 classification, status epilepticus (SE) is a seizure that lasts longer than 5 min or a frequency of more than one seizure within 5 min, without returning to a normal level of consciousness between episodes. In this study, we aimed to evaluate the prognostic factors of SE and compare our patients with those of patients treated internationally with the modified status epilepticus severity score (mSTESS) to determine the reliability of this scoring system. The medical records of patients aged 1 month-17 years with SE who were treated at Çukurova University-Balcalı Training and Research Hospital between September 2018 and September 2021 and who were followed in the intensive care unit were included in the study.

View Article and Find Full Text PDF

Aims And Background: Fostering a positive dental attitude in children to enhance their oral health status and engaging them positively throughout their dental experience is the cornerstone of pediatric dentistry practices. The behavior of the child in a dental setting depends upon their emotional, psychological, and mental developmental state. Children with special health needs tend to have more anxiety than healthy children.

View Article and Find Full Text PDF

Background Consanguineous marriages, defined as unions between closely related individuals, are influenced by a complex interplay of cultural, social, economic, religious, and demographic factors. These marriages are prevalent among communities such as Hindus, Muslims, Jews, Buddhists, Christians, and Parsis in Southern and Western Asia, with significant regional variations within India. There is a lack of appropriate decision-making among women in consanguineous unions, particularly those with a low level of educational attainment, which leads to an increase in the prevalence of consanguineous marriages.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!