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Immunohistochemistry-based molecular subtypes of urothelial carcinoma derive different survival benefit from platinum chemotherapy.
J Pathol Clin Res
January 2025
Department of Urology, University of Duisburg-Essen, Essen, Germany.
Distinct molecular subtypes of muscle-invasive bladder cancer (MIBC) may show different platinum sensitivities. Currently available data were mostly generated at transcriptome level and have limited comparability to each other. We aimed to determine the platinum sensitivity of molecular subtypes by using the protein expression-based Lund Taxonomy.
View Article and Find Full Text PDFClinical factors for all-cause mortality in people with schizophrenia: A retrospective cohort study between 2013 and 2021.
Asian J Psychiatr
December 2024
The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. Electronic address:
Background: Schizophrenia is a severe mental illness associated with significantly elevated mortality rates. However, factors related to the mortality risk among people with schizophrenia in low and middle-income countries remain to be examined. This study aims to explore the clinical factors for all-cause mortality in people with schizophrenia.
View Article and Find Full Text PDFBackground: Obesity shows significant association with depression elevating morbidity burden. Obesity surgery (OS) has been proven as an effective therapy reducing weight as well as depression prevalence rates, though the latter decrease appears to be unstable over time. For a better interpretation of the time trend, data on depression prevalence in OS-patients for the period before the surgery are needed.
View Article and Find Full Text PDFAnti-migraine medications safety during pregnancy in the US.
Front Pharmacol
December 2024
Independent Consultant, Los Angeles, CA, United States.
Background: Specific antimigraine medications (dihydroergotamine (DHE), triptans) have been associated with adverse pregnancy outcomes in individual studies but lack of consensus remains.
Objectives: Quantify the risk of prematurity, low birth weight (LBW), major congenital malformations (MCM), and spontaneous abortions (SA) associated with gestational use of DHE or triptans in a privately insured cohort of pregnant women in the US.
Methods: We conducted a cohort study within the US Merative MarketScan Research Database (2011-2021), composed of a nationally representative sample of patients with employer-provided health insurance.
Triglycerides and the Risk of Atherosclerotic Cardiovascular Events Across Different Risk Categories.
J Atheroscler Thromb
December 2024
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University.
Aims: To investigate the association between triglyceride levels and major adverse cardiovascular events (MACE) in primary and secondary prevention cohorts.
Methods: This retrospective study was conducted with a nationwide health insurance claims database, which included approximately 3.8 million participants with medical checkups between January 2005 and August 2020 in Japan.
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