Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479885 | PMC |
| http://dx.doi.org/10.1113/jphysiol.2005.103184 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An excitatory neural circuit for descending inhibition of itch processing.
Cell Rep
December 2024
Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China. Electronic address:
Itch serves as a self-protection mechanism against harmful external agents, whereas uncontrolled and persistent itch severely influences the quality of life of patients and aggravates their diseases. Unfortunately, the existing treatments are largely ineffective. The current difficulty in treatment may be closely related to the fact that the central neural mechanisms underlying itch processing, especially descending inhibition of itch, are poorly understood.
View Article and Find Full Text PDFFull moon mesencephalon sign: a transient cytotoxic lesion in a hemodialysis patient with newly diagnosed atrial fibrillation and severe stenosis of the right vertebral artery.
Neurol Sci
December 2024
Department of Neurology, Martin Gropius Hospital, Eberswalde, Germany.
Brain cytotoxic edema is a neuroradiological sign secondary to variegate diseases ranging from migraine to fulminant Listeria rhombencephalitis. The tempestive identification of its underlying cause is vital for an effective treatment as any delay may be fatal. However, the lack of distinctive imaging biomarkers and the paucity of reports pose a significant challenge in its diagnosis and frequently lead to a misdiagnosis particularly with the more common acute ischemic stroke.
View Article and Find Full Text PDFRegulation of CeA-Vme projection in masseter hyperactivity caused by restraint stress.
Front Cell Neurosci
November 2024
State Key Laboratory of Oral and Maxillofacial Reconstruction and Regneration, Department of General Dentistry and Emergency, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
The overactivity of the masticatory muscles (bruxism or teeth clenching) is associated with stress exposure, and often leading to consistent muscle pain. However, the neural mechanism underlining it is not fully understood. The central amygdala (CeA), which is linked to stress-induced behaviors and physical reactions, projects directly to the mesencephalic trigeminal nucleus (Vme), which is crucial for oral-motor coordination.
View Article and Find Full Text PDFCharacterization of direct Purkinje cell outputs to the brainstem.
bioRxiv
November 2024
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- Purkinje cells (PCs) mainly connect to cerebellar nuclei but also have direct links to the brainstem, which haven't been fully explored until now.
- Using a PC-specific genetic tool, researchers found that PC synapses are widespread in the brainstem, particularly around vestibular and parabrachial nuclei, but the density varies by region.
- Despite previous beliefs, PCs show minimal synaptic connections to some brainstem neurons, suggesting they selectively influence certain areas and specific behaviors rather than innervating all neuron types uniformly.
A potential candidate for prevention of PTSD: Prazosin prevents learned helplessness behavior in adult male rats.
Psychiatry Res
January 2025
Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA, United States.
Post-Traumatic Stress Disorder (PTSD) is a debilitating psychiatric disorder that arises following exposure to an extreme stress. PTSD is characterized by five primary trauma-related symptom clusters, including symptoms of negative mood and hyperresponsivity to the traumatic event. Regrettably, the current therapy options are not highly effective.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!