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Weekly dihydroartemisinin-piperaquine versus monthly sulfadoxine-pyrimethamine for malaria chemoprevention in children with sickle cell anaemia in Uganda and Malawi (CHEMCHA): a randomised, double-blind, placebo-controlled trial.
Lancet Infect Dis
December 2024
Training and Research Unit of Excellence, Blantyre, Malawi; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
Background: In many sub-Saharan African countries, it is recommended that children with sickle cell anaemia receive malaria chemoprevention with monthly sulfadoxine-pyrimethamine or daily proguanil as the standard of care. However, the efficacy of these interventions is compromised by high-grade antifolate resistance of Plasmodium falciparum and poor adherence. We aimed to compare the efficacy of weekly dihydroartemisinin-piperaquine and monthly sulfadoxine-pyrimethamine for the prevention of clinical malaria in children with sickle cell anaemia in areas with high-grade sulfadoxine-pyrimethamine resistance of P falciparum in Uganda and Malawi.
View Article and Find Full Text PDFCan Emotionally Intelligent Mental Health Nurse Leaders Influence Workforce Sustainability? A Scoping Review.
Int J Ment Health Nurs
February 2025
School of Nursing & Midwifery, Institute for Health Transformation, Deakin University, Burwood, Victoria, Australia.
Due to a global shortage of nursing staff, there is renewed attention on the impact of leadership and management styles on the sustainability of the nursing workforce. Emotional intelligence (EI), the ability to manage both your own emotions and to perceive and understand the emotions of others, has been implicated as a nursing management style impacting reduced turnover and greater nurse wellbeing. Despite these promising findings, there is a dearth of research on the role of emotionally intelligent leadership on the retention of mental health nurses.
View Article and Find Full Text PDFThe potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and insomnia: study protocol for a randomized clinical trial.
BMC Complement Med Ther
December 2024
College of Medicine, University of Florida, Gainesville, FL, USA.
Background: As the primary cause of various preventable illnesses, smoking results in approximately five million premature deaths each year in the US and a multitude of adults living with serious illness. The majority of smokers know the health risks associated with smoking and intend to quit. However, quitting is very difficult partly because of insomnia and stress associated with it.
View Article and Find Full Text PDFUsing an SMS to improve bowel cancer screening: the acceptability and feasibility of a multifaceted intervention.
Fam Pract
December 2024
Department of General Practice and Primary Care, Level 3, Medical Building, University of Melbourne, Victoria 3010, Australia.
Background: The Australian National Bowel Cancer Screening Program sends an immunochemical faecal occult blood test to Australians aged 50-74 years to screen for bowel cancer, but uptake is low (40.9%). The SMARTscreen trial demonstrated that sending a short messaging services (SMS) prompt from the participant's general practitioner (GP) increased the proportion of kit returns by 16.
View Article and Find Full Text PDFEffectiveness and acceptability of a 24-h interval versus a 48-h interval between mifepristone intake and misoprostol administration for in-hospital abortion at 9-20 gestational weeks: an international, open-label, randomised, controlled, non-inferiority trial.
Lancet Glob Health
January 2025
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; WHO Collaborating Centre, Karolinska University Hospital, Stockholm, Sweden.
Background: Optimising management of second-trimester medical abortion is important, as complications increase with gestational age. We aimed to compare a 24-h interval with a 48-h interval between mifepristone intake and misoprostol administration in in-hospital, second-trimester medical abortion for effectiveness and acceptability.
Methods: This open-label, randomised, controlled, non-inferiority trial was conducted at nine hospitals in India, Sweden, Thailand, and Viet Nam among adults undergoing medical abortion for a singleton viable pregnancy at a gestation of between 9 weeks and 20 weeks.
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