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Leukomelanoderma Resembling Hyperpigmented Mycosis Fungoides.

Acta Dermatovenerol Croat

March 2024

Kozo Nakai, MD, PhD, Professor and Chairman, Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan;

Acquired circumscribed hyperpigmented patches and plaques have various differential diagnoses, including post-inflammatory hyperpigmentation and mycosis fungoides (MF). Leukomelanoderma is an uncommon cutaneous condition in which the pathogenesis is not fully elucidated. It has been reported that leukomelanoderma occurs after allergic contact dermatitis from hydroquinone or acute cutaneous graft-versus-host disease (1,2).

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Article Synopsis
  • Café-au-lait macules (CALMs) are benign brown birthmarks that can cause cosmetic distress, especially in skin of color patients, and the 730-nm picosecond titanium sapphire laser offers a new treatment option for these lesions.
  • A retrospective study was conducted on 14 patients, with an average age of 27.4 years, showing a 26%-50% improvement in their CALMs after about 4.3 treatment sessions, with some achieving full clearance.
  • Despite overall positive outcomes, challenges included varying effectiveness based on CALM subtype and the potential for recurrence or transient pigmentation issues following treatment.
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Pigmentary demarcation lines (PDL), or Voigt-Futcher lines, are lines that mark an abrupt transition between hyperpigmented skin and normal skin. PDLs are more common in Japanese and dark-skinned individuals. Eight types have been described (A-H); Type B is located on the posteromedial aspect of the lower extremities; it is more common in women and is the one most frequently associated with pregnancy.

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