Little is known about researchers' understanding of confidence intervals (CIs) and standard error (SE) bars. Authors of journal articles in psychology, behavioral neuroscience, and medicine were invited to visit a Web site where they adjusted a figure until they judged 2 means, with error bars, to be just statistically significantly different (p < .05). Results from 473 respondents suggest that many leading researchers have severe misconceptions about how error bars relate to statistical significance, do not adequately distinguish CIs and SE bars, and do not appreciate the importance of whether the 2 means are independent or come from a repeated measures design. Better guidelines for researchers and less ambiguous graphical conventions are needed before the advantages of CIs for research communication can be realized.
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http://dx.doi.org/10.1037/1082-989X.10.4.389 | DOI Listing |
Allergol Select
January 2025
Department of Dermatology, Venereology and Allergology, University Hospital Leipzig, Leipzig, and.
Aim: In case of systemic anaphylactic reactions after Hymenoptera stings, patients should be provided with an adrenaline autoinjector (AAI). We aimed to evaluate the education and handling competence of patients in a real-world setting.
Materials And Methods: Patients with Hymenoptera venom allergy presenting for the first time in our clinic with a previously prescribed emergency kit including an AAI were interviewed using a standardized questionnaire and were asked to demonstrate the AAI use with a dummy.
Sensors (Basel)
December 2024
College of Automation & College of Artificial Intelligence, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.
The design and study of pulsed eddy current sensors for detecting surface defects in small-diameter rods are highly significant. Accurate detection and identification of surface defects in small-diameter rods may be attained by the ongoing optimization of sensor design and enhancement of detection technologies. This article presents the construction of a non-coaxial differential eddy current sensor (Tx-Rx sensor) and examines the detection of surface defects in a small diameter bar.
View Article and Find Full Text PDFSLAS Discov
January 2025
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA; University of Pittsburgh Hillman Cancer Center, Pittsburgh, PA 15232, USA. Electronic address:
Development, optimization, and calibration of human transient receptor potential (TRP) channel Ca mobilization assays for TRPM8, TRPV1, and TRPA1 are described. Heterologous expression of hTRPM8 in HEK293T cells was required for anti-TRPM8 antibody staining and TRPM8 agonist induced Ca mobilization signals which were both used to optimize transfection efficiency. FLIPR Calcium 6 dye concentration, loading time, and TRPM8 transfected cell seeding density were optimized and a DMSO tolerance of ≤0.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Jiangsu Key Laboratory of Structure Engineering, Suzhou University of Science and Technology, Suzhou 215011, China.
In practical engineering, due to quality inspections of connections between prefabricated components and construction errors, reserved reinforcing bars in the transition layer may be partially insufficient or even completely absent. This defect significantly impacts the structural performance of sleeve connections, particularly under tensile or shear forces. This paper proposes a novel reinforcement method to address the connection issues caused by the absence of reserved reinforcing bars in the transition layer and verifies its feasibility through systematic experiments.
View Article and Find Full Text PDFPRX Life
March 2024
Joseph Henry Laboratories of Physics and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton NJ 08544 USA.
In a developing embryo, information about the position of cells is encoded in the concentrations of morphogen molecules. In the fruit fly, the local concentrations of just a handful of proteins encoded by the gap genes are sufficient to specify position with a precision comparable to the spacing between cells along the anterior-posterior axis. This matches the precision of downstream events such as the striped patterns of expression in the pair-rule genes, but is not quite sufficient to define unique identities for individual cells.
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