Augmentationindex (AIx) and Pulse Wave Velocity (PWV) give much more information on the function of the arterial tree than that obtained by blood pressure recordings. The rediscovered value of arterial stiffness measured by means of AIx or PWV is now proven as an independent cardiovascular risk factor and helps to differentiate patients at risk and their cardiovascular treatment offer. In the last decade, the methods to measure and to calculate AIx and PWV have become increasingly simple. But as the different methods use different strategies for measuring and calculating these parameters, the results concerning the same term vary, depending on the device used. We undertook nearly simultaneous recordings of AIx in 400 and of PWV in 100 treated hypertensive patients with the very new TensioClinic device developed by M. Illyés, and compared those data with measurements obtained by the SphygmoCor device. The absolute values of m (mean) and SD (standard deviation) of AIx were when TensioClinic was used m: -6.2 % +/- SD:37.9 % and by SphygmoCor m: 26,2 % +/- SD: 11,8 %. The differences were caused by the different methods. As both devices measure the same quality of vascular function, the results correlate closely with a correlation coefficient r = 0.77. In PWV the results of Aortic PWV measured by TensioClinic were m: 9.1 +/- SD: 1.8m/sec and of brachial PWV measured by SphygmoCor: 8.4 +/- SD: 1.5 m/sec. As in AIx, these results were also different, but in contrast to AIx they did not correlate (r = -0.04) because PWV depend on the artery and its physical characteristics, and we
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Blood Press
January 2025
Jagiellonian University Medical College, 1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Kraków, Poland.
Purpose: Ventricular-arterial coupling (VAC) is a crucial concept in cardiovascular physiology, representing the dynamic interaction between the left ventricle and the arterial system. This comprehensive literature review explores the changes in VAC with aging and various cardiovascular diseases (CVDs).
Materials And Methods: This literature review covers studies on changes in VAC with age and common CVDs such as arterial hypertension, atrial fibrillation, heart failure with preserved and reduced ejection fraction and aortic stenosis.
Curr Atheroscler Rep
January 2025
Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.
Purpose Of Review: The exposome refers to the total environmental exposures a person encounters throughout life, and its relationship with human health is increasingly studied. This non-systematic review focuses on recent research investigating the effects of environmental factors-such as air pollution, noise, greenspace, neighborhood walkability, and metallic pollutants-on atherosclerosis, a major cause of cardiovascular disease.
Recent Findings: Studies show that long-term exposure to airborne particulate matter can impair endothelial function and elevate adhesion molecule levels, leading to vascular damage.
Am J Clin Nutr
January 2025
Department of Nutrition, Center for Big Data and Population Health of IHM, The Second Affiliated Hospital of Anhui Medical University, School of Public Health, Anhui Medical University, Hefei, China. Electronic address:
Background: Hippuric acid (HA), a host-microbe co-metabolite, normally derives from gut microbial catabolism of dietary polyphenols.
Objectives: We investigated the potential interplay between dietary polyphenols and gut microbiota on circulating HA levels, and examined the associations between serum concentrations of HA and cardiometabolic risk markers.
Methods: In a 1-year cohort of 754 community-dwelling adults, serum HA and its precursor [benzoic acid (BA)] and fecal microbiota were assayed using liquid chromatography-tandem mass spectrometry and 16S ribosomal RNA sequencing, respectively.
Biomech Model Mechanobiol
January 2025
Cardiac Surgery Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Percutaneous coronary interventions in highly calcified atherosclerotic lesions are challenging due to the high mechanical stiffness that significantly restricts stent expansion. Intravascular lithotripsy (IVL) is a novel vessel preparation technique with the potential to improve interventional outcomes by inducing microscopic and macroscopic cracks to enhance stent expansion. However, the exact mechanism of action for IVL is poorly understood, and it remains unclear whether the improvement in-stent expansion is caused by either the macro-cracks allowing the vessel to open or the micro-cracks altering the bulk material properties.
View Article and Find Full Text PDFCureus
December 2024
Department of Oral Medicine, Nihon University School of Dentistry, Tokyo, JPN.
Calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome, a systemic sclerosis subtype, features skin thickening, vascular issues, and organ involvement, causing complications in the gastrointestinal and musculoskeletal systems. Herein, we present a rare case of oral candidiasis, with CREST syndrome. The patient presented with xerostomia, tongue erythema, and burning pain.
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