AI Article Synopsis
- A new method is introduced to efficiently synthesize the naturally occurring form of grenadamide using a specific starting material called a 3,6-disubstituted 1,2-dioxine.
- This synthesis technique enables the creation of various grenadamide derivatives by changing the cyclopropyl carbons at positions 2 and 3, allowing access to both enantiomers.
- The study also provides insights into how phosphorus aids in the process of deprotonation for 1,2-dioxines.
Article Abstract
A concise, high yielding route to the naturally occurring enantiomer of grenadamide utilizing a 3,6-disubstituted 1,2-dioxine starting material is presented. The route allows for ease in synthesizing grenadamide derivatives varying at cyclopropyl carbons 2 and 3, with access to both enantiomers. Evidence for phosphorus-assisted deprotonation of 1,2-dioxines is also discussed.
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| http://dx.doi.org/10.1039/b513774h | DOI Listing |
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